Efeitos da suplementação de probióticos sobre o desempenho esportivo: uma revisão narrativa
Resumo
A microbiota intestinal é caracterizada pelo conjunto de micro-organismos (bactérias, fungos, leveduras, fagos e protozoários) que naturalmente habitam o trato gastrointestinal de seres humanos e animais. A diversidade e qualidade da microbiota intestinal estão diretamente relacionadas com os hábitos alimentares, bem como ao nível de treinamento dos indivíduos. O exercício físico moderado parece promover uma maior diversidade microbiana intestinal, além de uma série de reações anti-inflamatórias, melhora do metabolismo dos carboidratos e prevenção de doenças associadas ao sedentarismo. Entretanto, o exercício físico em excesso promove a alteração ou desequilíbrio da microbiota (disbiose) e favorece o aumento da permeabilidade da barreira intestinal (leaky gut). Esta condição está relacionada com o aumento de citocinas pró inflamatórias e produção de espécies reativas de oxigênio (ROS), imunossupressão e até mesmo com o aumento da lesão das fibras musculares. A microbiota intestinal pode auxiliar na redução do estresse oxidativo ocasionado pelo exercício excessivo. Algumas cepas de bactérias apresentam propriedades antioxidantes por meio da expressão de enzimas antioxidantes e modulação da inflamação causada por citocinas pró-inflamatórias. Tendo em vista os mecanismos envolvidos entre o exercício físico e microbiota intestinal, a suplementação de cepas bacterianas parece impactar no desempenho esportivo dos atletas à medida que auxilia no controle da inflamação, nos processos de recuperação pós exercício e no suporte do sistema imunológico.
Referências
-Allen, J.M.; Mailing, L.J.; Niemiro, G.M.; Moore, R.; Cook, M.D.; White, B.A.; Holscher, H.; Woods, J. Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans. Medicine and Science in Sports and Exercise. Vol. 50. Num. 4. 2018. p. 747-757.
-Barton, W.; Penney, N.C.; Cronin, O.; Garcia-Perez, I.; Molloy, M.G.; Holmes, E., Shanahan F., Cotter P.D., O’Sullivan O. The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level. Gut. Vol. 67. Num. 4. 2018. p. 625-33.
-Carabotti, M.; Scirocco, A.; Maselli, M.A.; Severi, C. The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems. Annals of Gastroenterology. Vol. 28. Num. 2. 2015. p. 203-209.
-Carvalho, B.M.; Abdalla Saad, M.J. Influence of Gut microbiota on subclinical inflammation and insulin resistance. Mediators of Inflammation. Vol. 2013. 2013. p. 1-13.
-Chassard, C.; Lacroix, C. Carbohydrates and the human gut microbiota. Current Opinion in Clinical Nutrition and Metabolic Care. Vol. 16. Num. 4. 2013. p. 453-460.
-Churchward-Venne, T.A.; Burd, N.A.; Mitchell, C.J.; West, D.W.D.; Philp, A.; Marcotte, G.R.; Baker, S.; Baar, K.; Phillips, S. Supplementation of a suboptimal protein dose with leucine or essential amino acids: Effects on myofibrillar protein synthesis at rest and following resistance exercise in men. Journal of Physiology. Vol. 590. Num. 11. 2012. p. 2751-2765. https://doi.org/10.1113/jphysiol.2012.228833.
-Clancy, R.L.; Gleeson, M.; Cox, A.; Callister, R.; Dorrington, M.; D’Este, C.; Pang, G.; Pyne, D.; Fricker, P.; Henriksson, A. Reversal in fatigued athletes of a defect in interferon γ secretion after administration of Lactobacillus acidophilus. British Journal of Sports Medicine. Vol. 40. Num. 4. 2006. p. 351-354.
-Clarke, G.; Stilling, R.M.; Kennedy, P.J.; Stanton, C.; Cryan, J.F.; Dinan, T.G. Minireview: Gut microbiota: The neglected endocrine organ. Molecular Endocrinology. Vol. 28. Num. 8. 2014. p. 1221-1238.
-Clarke, S.F.; Murphy, E.F.; O’Sullivan, O.; Lucey, A.J.; Humphreys, M.; Hogan, A.; Hayes, A.; O’Reilly, M.; Jeffery, I.B.; Wood-Martin, R. Exercise and associated dietary extremes impact on gut microbial diversity. Gut. Vol. 63. Num. 12. 2014. p. 1913-1920.
-Costello, E.K.; Lauber, C.L.; Hamady, M.; Fierer, N.; Gordon, J.I.; Knight, R. Bacterial community variation in human body habitats across space and time. Science. Vol. 326. Num. 5960. 2009. p. 1694-1697.
-Cox, A.J.; Pyne, D.B.; Saunders, P.U.; Fricker, P.A. Oral administration of the probiotic Lactobacillus fermentum VRI-003 and mucosal immunity in endurance athletes. British Journal of Sports Medicine. Vol. 44. Num. 4. 2010. p. 222-226.
-Cronin, O.; Molloy, M.G.; Shanahan, F. Exercise, fitness, and the gut. Current Opinion in Gastroenterology. Vol. 32. Num. 2. 2016. p. 67-73.
-Dallas, D.C.; Sanctuary, M.R.; Qu, Y.; Khajavi, S.H.; Van Zandt, A.E.; Dyandra, M.; Frese, S.A.; Barile, D.; German, J.B. Personalizing protein nourishment. Critical Reviews in Food Science and Nutrition. Vol. 57. Num. 15. 2017. p. 3313-3331.
-Den Besten, G.; Van Eunen, K.; Groen, A.K.; Venema, K.; Reijngoud, D.J.; Bakker, B.M. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. Journal of Lipid Research. Vol. 54. Num. 9. 2013. p. 2325-2340.
-Eisenstein, M. Microbiome: Bacterial broadband. Nature. Vol. 533. 2016. p. S104-S106.
-Erridge, C.; Attina, T.; Spickett, C.M.; Webb, D.J. A high-fat meal induces low-grade endotoxemia: Evidence of a novel mechanism of postprandial inflammation. American Journal of Clinical Nutrition. Vol. 86. Num. 5. 2007. p. 1286-1292.
-Estaki, M.; Pither, J.; Baumeister, P.; Little, J.P.; Gill, S.K.; Ghosh, S.; Ahmadi-Vand, Z.; Marsden, K.; Gibson, D. Cardiorespiratory fitness as a predictor of intestinal microbial diversity and distinct metagenomic functions. Microbiome. Vol. 4. 2016. p. 1-13.
-Everard, A.; Belzer, C.; Geurts, L.; Ouwerkerk, J.P.; Druart, C.; Bindels, L.B.; Guiot, Y.; Derrien, M.; Muccioli, G.; Delzenne, N.; De Vos, W.; Cani, P. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proceedings of the National Academy of Sciences of the United States of America. Vol. 110. Num. 22. 2013. p. 9066-9071.
-Gentile, C.L.; Weir, T.L. The gut microbiota at the intersection of diet and human health. Science. Vol. 362. Num. 6416. 2018. p. 776-780.
-Gill, S.K.; Allerton, D.M.; Ansley-Robson, P.; Hemmings, K.; Cox, M.; Costa, R.J.S. Does short-term high dose probiotic supplementation containing Lactobacillus casei attenuate exertional-heat stress induced endotoxaemia and cytokinaemia? International Journal of Sport Nutrition and Exercise Metabolism. Vol. 26. Num. 3. 2016. p. 268-275.
-Huttenhower, C.; Gevers, D.; Knight, R.; Abubucker, S.; Badger, J.H.; Chinwalla, A.T. Structure, function and diversity of the healthy human microbiome. Nature. Vol. 486. Num. 7402. 2012. p. 207-214.
-Jäger, R.; Mohr, A.E.; Carpenter, K.C.; Kerksick, C.M.; Purpura, M.; Moussa, A.; Townsend, J.; Lamprecht, M.; West, N.; Black, K.; Gleeson, M.; Pyne, D.; Wells, S.; Arent, S.; Smith-Ryan, A.; Kreider, R.; Campbell, B.; Bannock, L.; Scheiman, J.; Wissent, C.; Pane, M.; Kalman, D.; Pugh, J.; er Haar, J.; Antonio, J. International Society of Sports Nutrition Position Stand: Probiotics. Journal of the International Society of Sports Nutrition. Vol. 16. Num. 1. 2019. p. 1-44.
-Jäger, R.; Purpura, M.; Stone, J.D.; Turner, S.M.; Anzalone, A.J.; Eimerbrink, M.J.; Pane, M.; Amoruso, A.; Rowloands, D.; Oliver, J. Probiotic Streptococcus thermophilus FP4 and Bifidobacterium breve BR03 supplementation attenuates performance and range-of-motion decrements following muscle damaging exercise. Nutrients. Vol. 8. Num. 10. 2016. p. 1-11.
-Karl, J.P.; Margolis, L.M.; Madslien, E.H.; Murphy, N.E.; Castellani, J.W.; Gundersen, Y.; Hoke, A.; Levangie, M.; Kumar, R.; Chakraborty, N.; Gautam, A.; Hammamieh, R.; Martini, S.; Montain, S.; Pasiakos, S. Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress. American Journal of Physiology - Gastrointestinal and Liver Physiology. Vol. 312. Num. 6. 2017. p. G559-G571.
-Kårlund, A.; Gómez-Gallego, C.; Turpeinen, A.M.; Palo-Oja, O.M.; El-Nezami, H.; Kolehmainen, M. Protein supplements and their relation with nutrition, microbiota composition and health: Is more protein always better for sportspeople? Nutrients. Vol. 11. Num. 4. 2019. p. 1-19.
-Klemenak, M.; Dolinšek, J.; Langerholc, T.; Di Gioia, D.; Mičetić-Turk, D. Administration of Bifidobacterium breve Decreases the Production of TNF-α in Children with Celiac Disease. Digestive Diseases and Sciences. Vol. 60. Num. 11. 2015. p. 3386-3392.
-Lamprecht, M.; Bogner, S.; Schippinger, G.; Steinbauer, K.; Fankhauser, F.; Hallstroem, S.; Schuetz, B.; Greilberger, J. Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men; a randomized, double-blinded, placebo-controlled trial. Journal of the International Society of Sports Nutrition. Vol. 9. 2012. p. 1-13.
-Lang, C.H.; Frost, R.A.; Nairn, A.C.; MacLean, D.A.; Vary, T.C. TNF-α impairs heart and skeletal muscle protein synthesis by altering translation initiation. American Journal of Physiology - Endocrinology and Metabolism. Vol. 282. Num. 2 45-2. 2002. p. 336-347.
-Li, J.; Jia, H.; Cai, X.; Zhong, H.; Feng, Q.; Sunagawa, S. An integrated catalog of reference genes in the human gut microbiome. Nature Biotechnology. Vol. 32. Num. 8. 2014. p. 834-841.
-Maathuis, A.J.H.; Keller, D.; Farmer, S. Survival and metabolic activity of the GanedenBC30 strain of Bacillus coagulans in a dynamic in vitro model of the stomach and small intestine. Beneficial Microbes. Vol. 1. Num. 1. 2010. p. 31-36.
-Mach, N.; Fuster-Botella, D. Endurance exercise and gut microbiota: A review. Journal of Sport and Health Science. Vol. 6. Num. 2. 2017. p. 179-197.
-Main, L.C.; Dawson, B.; Heel, K.; Grove, J.R.; Landers, G.J.; Goodman, C. Relationship between inflammatory cytokines and self-report measures of training overload. Research in Sports Medicine. Vol. 18. Num. 2. 2010. p. 127-139.
-Małkiewicz, M.A.; Szarmach, A.; Sabisz, A.; Cubała, W.J.; Szurowska, E.; Winklewski, P.J. Blood-brain barrier permeability and physical exercise. Journal of Neuroinflammation. Vol. ;6. Num. 1. 2019. p. 1-16.
-Marshall, H.; Chrismas, B.C.R.; Suckling, C.A.; Roberts, J.D.; Foster, J.; Taylor, L. Chronic probiotic supplementation with or without glutamine does not influence the eHsp72 response to a multi-day ultra-endurance exercise event. Applied Physiology, Nutrition and Metabolism. Vol. 42. Num. 8. 2017. p. 876-883.
-Marshall, J.C.; Kelch, R.P. Gonadotropin-Releasing Hormone: Role of Pulsatile Secretion in the Regulation of Reproduction. New England Journal of Medicine. Vol. 306. Num. 7. 1986. p. 424-426.
-Martarelli, D.; Verdenelli, M.C.; Scuri, S.; Cocchioni, M.; Silvi, S.; Cecchini, C.; Pompei, P. Effect of a probiotic intake on oxidant and antioxidant parameters in plasma of athletes during intense exercise training. Current Microbiology. Vol. 62. Num. 6. 2011. p. 1689-1696.
-Michalickova, D.; Minic, R.; Dikic, N.; Andjelkovic, M.; Kostic-Vucicevic, M.; Stojmenovic, T.; Nikolic, I.; Djordjevic, B. Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: A randomized, double-blind, placebo-controlled trial. Applied Physiology, Nutrition and Metabolism. Vol. 41. Num. 7. 2016. p. 782-789.
-Moloney, R.D.; Desbonnet, L.; Clarke, G.; Dinan, T.G.; Cryan, J.F. The microbiome: Stress, health and disease. Mammalian Genome. Vol. 25. Num. 1-2. 2014. p. 49-74.
-Monteiro, R.; Azevedo, I. Chronic inflammation in obesity and the metabolic syndrome. Mediators of Inflammation. Vol. 2010. 2010. p. 1-10.
-Morgan, J.A.; Corrigan, F.; Baune, B.T. Effects of physical exercise on central nervous system functions: a review of brain region specific adaptations. Journal of Molecular Psychiatry. Vol. 3. Num. 1. 2015. p. 1-13.
-Muhamad, A.; Gleeson, M. Effects of a 14-strain Probiotics Supplement on Salivary Antimicrobial Proteins at Rest and in Response to an Acute Bout of Prolonged Exercise. International Journal of Sports Science. Vol. 2014. Num. 2. 2014. p. 60-66.
-O’Brien, K.V.; Stewart, L.K.; Forney, L.A.; Aryana, K.J.; Prinyawiwatkul, W.; Boeneke, C.A. The effects of postexercise consumption of a kefir beverage on performance and recovery during intensive endurance training. Journal of Dairy Science. Vol. 98. Num. 11. 2015. p. 7446-7449.
-Oliveira, E.P.; Burini, R.C.; Jeukendrup, A. Gastrointestinal complaints during exercise: Prevalence, etiology, and nutritional recommendations. Sports Medicine. Vol. 44. 2014. p. 79-85.
-Parkes, G.C. The Role of Probiotics in the Treatment of Irritable Bowel Syndrome. Bioactive Foods in Promoting Health. Vol. 38. 2010. p. 513-528.
-Peternelj, T.T.; Coombes, J.S. Antioxidant supplementation during exercise training: Beneficial or detrimental? Sports Medicine. Vol. 41. Num. 12. 2011. p. 1043-1069.
-Przewłócka, K.; Folwarski, M.; Kaźmierczak-Siedlecka, K.; Skonieczna-żydecka, K.; Kaczor, J.J.J.J.; Zydecka, K.S. Gut-Muscle Axis Exists and May Affect Skeletal. Nutrients. Vol. 12. Num. 5. 2020. p. 1-19.
-Purvis, D.; Gonsalves, S.; Deuster, P.A. Physiological and Psychological Fatigue in Extreme Conditions: Overtraining and Elite Athletes. PM and R. Vol. 2. Num. 5. 2010. p. 442-450.
-Rajilić-Stojanović, M.; de Vos, W.M. The first 1000 cultured species of the human gastrointestinal microbiota. FEMS Microbiology Reviews. Vol. 38. Num. 5. 2014. p. 996-1047.
-Roberts, J.D.; Suckling, C.A.; Peedle, G.Y.; Murphy, J.A.; Dawkins, T.G.; Roberts, M.G. An exploratory investigation of endotoxin levels in novice long distance triathletes,and the effects of a multi-strain probiotic/prebiotic,antioxidant intervention. Nutrients. Vol. 8. Num. 11. 2016. p. 1-18.
-Salehzadeh, K. The Effects of Probiotic Yogurt Drink on Lipid Profile, CRP and Record Changes in Aerobic Athletes. International Journal of Life Sciences. Vol. 9. Num. 4. 2015. p. 32-7.
-Szuhanya, K.L.; Bugattia, M.; Otto, M.W. A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor. Bone. Vol. 23. Num. 1. 2008. p. 1-7.
-Townsend, J.; Bender, D.; Vantrease, W.; Sapp, P.; Toy, A.; Woods, C.; Johnson, K. Effects of Probiotic (Bacillus subtilis DE111) Supplementation on Immune Function, Hormonal Status, and Physical Performance in Division I Baseball Players. Sports. Vol. 6. Num. 3. 2018. p. 70-88.
-Turner, J.R. Intestinal mucosal barrier function in health and disease. Nature Reviews Immunology. Vol. 9. Num. 11. 2009. p. 799-809.
-Ulrich-Lai, Y.M.; Herman, J.P. Neural regulation of endocrine and autonomic stress responses. Nature Reviews Neuroscience. Vol. 10. Num. 6. 2009. p. 397-409.
-Ursell, L.K.; Metcalf, J.L.; Parfrey, L.W.; Knight, R. Defining the human microbiome. Nutrition Reviews. Vol. 70. 2012. p. S38-S34.
-Valente-Silva, P.; Ruas, J.L. Tryptophan-kynurenine metabolites in exercise and mental health. Research and Perspectives in Endocrine Interactions. Vol. 1 2017. p. 83-91.
-West, N.P.; Pyne, D.B.; Cripps, A.W.; Hopkins, W.G.; Eskesen, D.C.; Jairath, A.; Christophersen, C.; Conlon, M.; Fricker, P. Lactobacillus fermentum (PCC) supplementation and gastrointestinal and respiratory-tract illness symptoms: A randomised control trial in athletes. Nutrition Journal. Vol. 10. Num. 1. 2011. p. 1-11.
-Wu, G.D.; Chen, J.; Hoffmann, C.; Bittinger, K.; Chen, Y.Y.; Keilbaugh, S.A. Linking long-term dietary patterns with gut microbial enterotypes. Science. Vol. 334. Num. 6052. 2011. p. 105-108.
-Wu, G.D.; Compher, C.; Chen, E.Z.; Smith, S.A.; Shah, R.D.; Bittinger, K.; Chehound, C.; Albenberg, L.; Nessel, L.; Gilroy, E.; Star, J.; Weljie, A.; Flint, H.; Metz, D.; Bennett, M.; Li, H.; Bushman, F.; Lewis, J. Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production. Gut. Vol. 65. Num. 1. 2016. p. 63-72.
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