The supplementation of conjugated linoleic acid (CLA) has positive effects in obese and does not promote amendment on body composition in healthy subjects practitioners of physical activity
Abstract
Objective: The present study has the objective of reviewing the scientific literature found in Medline, Scielo and Lilacs about principal effects of CLA in physical activity practitioners. Literature Review: Most of studies related to CLA are focused on its results between groups of obese – BMI ≥ 30 Kg/m). Recent studies indicates that CLA supplementation in obese people for 12 week, with a minimal dose of 3.4 g/d, showed positive results in anthropometric measurements as weight, BMI and Body Fat. Following other line of studies, the alternative use of CLA enriched foods showed no significant results in anthropometric variables. Finally, when supplemented with 3.0 and 6.0 g/dia, healthy subjects practitioners of physical activity had no significant results related to body composition. Beside this, most studies obtained worries results related to serum lipid profiles such as increased Total Cholesterol, LDL and decreased HDL in supplemented subjects. Conclusion: Based on Body Compo-sition, CLA supplementation has no effects in healthy exercised individuals. What has been proved is a positive function in the lost - and not in the prevention of weight gain in overweight and obese people supplemented with 3.4 g/d, for at least twelve weeks. Beside positive effects, it is important to consider its injuries on lipid profile.
References
- Belury, M.A.; Mahon, A.; Banni, S. The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. Journal of Nutrition. Vol. 133(suppl). 2003. p. 257S– 260S.
- Blankson, H.; e colaboradores. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. Journal of Nutrition. Vol. 130. 2000. p. 2943–2948.
- Chung, S.; e colaboradores. Conjugated Linoleic Acid Promotes Human Adipocyte Insulin Resistance through NF_B-dependent Cytokine Production. The Journal of Biological Chemistry. Vol. 280. Num. 46. 2005. p. 38445–38456.
- Close, R.N.; e colaboradores. Conjugated linoleic acid supplementation alters the 6-mo change in fat oxidation during sleep. American Journal of Clinical Nutrition. Vol. 86. 2007. p. 797–804.
- Desroches, S.; e colaboradores. Lack of effect of dietary conjugated linoleic acids naturally incorporated into butter on the lipid profile and body composition of overweight and obese men. American Journal of Clinical Nutrition. Vol. 82. 2005. p. 309–319.
- Gaullier, J.M.; Halse, J.; Hoye, K.; e colaboradores. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. American Journal of Clinical Nutrition. Vol. 79. 2004. p 1118 –1125.
- Gaullier, J.M.; Halse, J.; Hoye, K.; e colaboradores. Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. Journal of Nutrition. Vol. 135. 2005. p. 778–784.
- Gaullier, J.M.; Halse, J.; Hoye, K.; e colaboradores. Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese. British Journal of Nutrition. Vol. 97. 2006. p, 550–560.
- Jiang, J.; e colaboradores. Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue. American Journal of Clinical Nutrition. Vol. 70. 1999. p. 21–27.
- Kamphuis, M.M.J.W.; Lejeune, M.P.G.M.; Saris, W.H.M.; Westerterp-Plantenga, M.S. The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects International Journal of Obesity. Vol. 27. 2003. p. 840–847.
- Kreider, R.B.; e colaboradores. Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. The Journal of Strength & Conditioning Research. Vol. 16. 2002. p. 325–34.
- Lambert, E.V.; e colaboradores. Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individuals. British Journal of Nutrition. Vol. 97. 2006. p.1001–1011.
- Larsen, T.M.; Toubro, S.; Gudmundsen, O.; Astrup, A. Conjugated linoleic acid supplementation for 1 y does not prevent weight or body fat regain. American Journal of Clinical Nutrition. Vol. 83. 2006. p. 606 –612.
- Laso, N.; e colaboradores. Effects of milk supplementation with conjugated linoleic acid (isomers cis-9, trans-11 and trans-10, cis-12) on body composition and metabolic syndrome. British Journal of Nutrition. Vol. 98. 2007. p.860–867.
- Loeffelholza, C.V.; e colaboradores. Influence of conjugated linoleic acids on body composition and selected serum and endocrine parameters in resistance-trained athletes. European Journal of Lipid Science and Technology. Vol. 105. 2003. p. 251–259.
- Malpuech-Brugere, C.; e colaboradores. Effects of two conjugated linoleic acid isomers on body fat mass in overweight humans. Obesity Research. Vol. 12. 2004. p. 591–598.
- Nazaré, J.A.; e colaboradores. Daily intake of conjugated linoleic acid-enriched yoghurts: effects on energy metabolism and adipose tissue gene expression in healthy subjects. British Journal of Nutrition. Vol. 97. 2007. p. 273–280.
- Pinkoski, C.; e colaboradores The Effects of Conjugated Linoleic Acid Supplementation during Resistance Training. Official Journal of the American College of Sports Medicine. Vol. 38. 2006. p. 339-48.
- Riserus, U.; e colaboradores. Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of metabolic syndrome: a randomized controlled trial. International Journal Obesity. Vol. 25. 2001. p. 1129–1135.
- Ritzenthaler, K.L.; Mcguire, M.K.; Falen, R.; Shultz, T.D.; e colaboradores. Estimation of Conjugated Linoleic Acid Intake by Written Dietary. Assessment Methodologies Underestimates Actual Intake Evaluated by Food Duplicate Methodology. Journal of Nutrition. Vol. 131. 2001. p.1548-1554.
- Smedman, A.E.M.; e colaboradores. Pentadecanoic acid as a marker for intake of milk fat: relation between intake of milk fat and metabolic risk factors. American Journal of Clinical Nutrition. Vol. 69. 1999. p. 22–29.
- Steck, S.E.; e colaboradores. Conjugated Linoleic Acid Supplementation for Twelve Weeks Increases Lean Body Mass in Obese Humans. Journal of Nutrition. Vol. 137. 2007. p. 1188-1193.
- Tricon, S.; e colaboradores. Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans. American Journal of Clinical Nutrition. Vol. 80. 2004. p. 614 –620.
- Wang, Y.W.; Jones, P.J. Conjugated linoleic acid and obesity control: efficacy and mechanisms. International Journal of Obesity and Related Metabolic Disorders. Vol. 28. 2004. p. 941– 955.
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