Hydroethanolic extract of s. Cumini (l.) Skeels entrecasca reduces wistar rats oxidative stress submitted to intervaled high intensity training
Abstract
O exercício físico de alta intensidade pode induzir o estresse oxidativo. Desta forma o uso de antioxidantes surge como alternativa para prevenir ou atenuar esse efeito. O objetivo principal do estudo foi avaliar o efeito de 21 dias de suplementação com extrato hidroetanólico da S. Cumini (EHE) em animais submetidos a um protocolo de 3 semanas de treinamento intervalado de alta intensidade (HIIT), 5 sessões por semana. Desta forma, foram utilizados ratos Wistar (250-300g) (CEPA: 58/2016). Os animais foram divididos aleatoriamente em 5 grupos (n=10): Sedentário (GC), sedentários tratados com EHE (GEHE), animais submetidos ao treinamento intervalado de alta intensidade (HIIT) (GE), animais submetidos ao (HIIT) e tratados com EHE (GE+EHE) e animais submetidos ao (HIIT) e tratados com quercetina (GE+Q). Os resultados demonstraram que o tratamento com EHE foi eficaz em reduzir o dano oxidativo nos tecidos avaliados: GT:14,49 ± 1,78 vs GT+EHE: 8,16 ± 0,54 nmol EqMDA/mL de sangue, no músculo (GT: 9,61 ± 1,51 vs GT+EHE 7,46 ± 0,69 nmol EqMDA/mg de tecido), fígado (GT: 40,85 ± 7,05 vs GT+EHE: 19,97 ± 5,95 nmol EqMDA/mg de tecido) e coração (GT: 18,06 ± 2,88 vs 12,64 ± 2,37 nmol EqMDA/mg de tecido), enquanto para a quantificação de grupamentos sulfidrilas os animais tratados com EHE tiveram seus grupos tiois preservados. Conclui-se que o tratamento diário durante 21 dias com EHE foi capaz de atenuar o dano oxidativo em ratos wistar submetidos a um protocolo de HIIT durante 3 semanas.
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