Glutamine supplementation in intestinal permeability related to physical activity

  • Leonardo Higashi Escola Paulista de Medicina-EPM, Universidade Federal de São Paulo-UNIFESP, São Paulo-SP, Brasil.
  • Igor Ribeiro Barcelos Escola Paulista de Medicina-EPM, Universidade Federal de São Paulo-UNIFESP, São Paulo-SP, Brasil.
  • Patrí­cia Cavalcante Silva Emiliozzi Escola Paulista de Medicina-EPM, Universidade Federal de São Paulo-UNIFESP, São Paulo-SP, Brasil.
  • Elisabeth Peres Biruel Escola Paulista de Medicina-EPM, Universidade Federal de São Paulo-UNIFESP, São Paulo-SP, Brasil.
  • Carlos Vicente Andreoli Escola Paulista de Medicina-EPM, Universidade Federal de São Paulo-UNIFESP, São Paulo-SP, Brasil.
Keywords: Glutamine, Intestinal permeability, Leaky gut, Exercise, Sport

Abstract

Long-term and exhaustive exercise, especially in warm environments, alters the intestinal permeability. There is evidence about the benefits of glutamine supplementation in the intestinal health of humans. The purpose of this review is to examine whether glutamine supplementation can aid intestinal integrity by decreasing the stress-related intestinal permeability markers of exercise. A literature review was performed of June 2019 following the methodological steps of the Systematic Review. This included searches on PMC/Medline, BVS, Sportdiscus. Selection criteria were randomized trials comparing glutamine versus placebo supplementation on intestinal permeability associated with physical activity. Three randomized controlled trials involving 25 people were identified. The trials were generally of good methodological quality. Glutamine supplementation decreased intestinal permeability markers compared to placebo, such as reduced urinary lactulose / rhamnose excretion ratio and prevented exercise-induced increased permeability, possibly through HSF-1 activation and consequently increased expression of HSP70 and ocludine. There was no difference in gastrointestinal symptoms. This review suggests that glutamine supplementation has a positive effect on intestinal permeability with both chronic and acute supplementation.

Author Biographies

Leonardo Higashi, Escola Paulista de Medicina-EPM, Universidade Federal de São Paulo-UNIFESP, São Paulo-SP, Brasil.

Curso de Especialização em Medicina Esportiva Aplicada às Ciências da Saúde, Universidade Federal de São Paulo-UNIFESP/EPM. São Paulo-SP, Brasil; Médico Titular em Endocrinologia e Metabologia pela SBEM, Titular em Nutrologia pela ABRAN Especialista em Clí­nica Médica.

Igor Ribeiro Barcelos, Escola Paulista de Medicina-EPM, Universidade Federal de São Paulo-UNIFESP, São Paulo-SP, Brasil.

Curso de Especialização em Medicina Esportiva Aplicada às Ciências da Saúde, Universidade Federal de São Paulo - UNIFESP/EPM. São Paulo-SP, Brasil; Médico Especialista em Clí­nica Médica e Endocrinologia e Metabologia pelo Hospital Alberto Rassi (HGG).

Patrí­cia Cavalcante Silva Emiliozzi, Escola Paulista de Medicina-EPM, Universidade Federal de São Paulo-UNIFESP, São Paulo-SP, Brasil.

Curso de Especialização em Medicina Esportiva Aplicada às Ciências da Saúde, Universidade Federal de São Paulo-UNIFESP/EPM, São Paulo-SP, Brasil; Médica, Especialista em Medicina Preventiva e Social pela ABRAMPAS.

Elisabeth Peres Biruel, Escola Paulista de Medicina-EPM, Universidade Federal de São Paulo-UNIFESP, São Paulo-SP, Brasil.

Especialista em Design Educacional pelo SENAC-SP (2016); Mestrado em Educação em Saúde pela Universidade Federal de São Paulo (2008), Bacharel em Biblioteconomia pela Fundação Escola de Sociologia e Polí­tica de São Paulo (2004); Bacharel em História pela Pontifí­cia Universidade Católica de São Paulo (1990) com licenciatura em História e Geografia; Coordena a área de Gestão e Planejamento em curso online da BIREME/OPAS/OMS. Professora na Disciplina de Metodologia Cientí­fica na Universidade Federal de São Paulo; orientando grupos de pesquisa em metodologia da Revisão Sistemática.

Carlos Vicente Andreoli, Escola Paulista de Medicina-EPM, Universidade Federal de São Paulo-UNIFESP, São Paulo-SP, Brasil.

Possui Graduação em Medicina pela Pontifí­cia Universidade Católica de São Paulo (1993), Curso de Especialização em Medicina Desportiva pela Escola Paulista de Medicina - EPM (1994); Especialização - Residência Médica em Ortopedia e Traumatologia pelo Instituto de Assistência Médica ao Servidor Público Estadual (1995-1997); Curso de Especialização Ortopedia e Traumatologia no Esporte pela Universidade Federal de São Paulo - UNIFESP (1998), realizou Mestrado em Ciências no Programa de Ortopedia e Traumatologia da UNIFESP (2005) e Doutorado pela UNIFESP (2010).

Coordenador do Curso de Especialização em Medicina Esportiva Aplicada às Ciências da Saúde; Prof. Adjunto, Disciplina de Medicina do Esporte e da Atividade Fí­sica; Departamento de Ortopedia e Traumatologia - UNIFESP/EPM.

 

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Published
2021-05-19
How to Cite
Higashi, L., Barcelos, I. R., Emiliozzi, P. C. S., Biruel, E. P., & Andreoli, C. V. (2021). Glutamine supplementation in intestinal permeability related to physical activity. RBNE - Brazilian Journal of Sports Nutrition, 14(84), 1-14. Retrieved from https://www.rbne.com.br/index.php/rbne/article/view/1576
Issue
Vol. 14 No. 84 (2020)
Section
Scientific Articles - Original

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