Glutamine supplementation in intestinal permeability related to physical activity
Abstract
Long-term and exhaustive exercise, especially in warm environments, alters the intestinal permeability. There is evidence about the benefits of glutamine supplementation in the intestinal health of humans. The purpose of this review is to examine whether glutamine supplementation can aid intestinal integrity by decreasing the stress-related intestinal permeability markers of exercise. A literature review was performed of June 2019 following the methodological steps of the Systematic Review. This included searches on PMC/Medline, BVS, Sportdiscus. Selection criteria were randomized trials comparing glutamine versus placebo supplementation on intestinal permeability associated with physical activity. Three randomized controlled trials involving 25 people were identified. The trials were generally of good methodological quality. Glutamine supplementation decreased intestinal permeability markers compared to placebo, such as reduced urinary lactulose / rhamnose excretion ratio and prevented exercise-induced increased permeability, possibly through HSF-1 activation and consequently increased expression of HSP70 and ocludine. There was no difference in gastrointestinal symptoms. This review suggests that glutamine supplementation has a positive effect on intestinal permeability with both chronic and acute supplementation.
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