The effect of Lepidium meyenii polysaccharide on fatigue: a systematic review
Abstract
Introduction: Fatigue can be defined as the inability to maintain a power activity or performance decrease and is associated to several factors, such as: change in the electrical action potential of the muscle fiber, muscle glycogen depletion and metabolite accumulation, in addition to increased free radical production and reactive oxygen species. Lepidium meyenii, a plant originally from the Peruvian Andes and used by local people for thousands of years, has been studied for its benefits, including its anti-fatigue effect. Objective: To determine, from the analysis of biochemical parameters, the anti-fatigue effect of the maca substrates. Materials and methods: Systematic review of experimental studies published between January 2009 and January 2019, searched in the main medical literature databases. Results: In all studies analyzed, the forced swimming time was longer in the groups of mice supplemented with maca substrates compared to the control groups. Regarding the biochemical parameters evaluated (BLA, BUN, LDH and LG), supplementation was beneficial, with anti-fatigue response in at least one sample of each work analyzed. Other parameters cited in the studies such as MG, BSR, MDA, CK and GSU-PX were positive, however, they were evaluated in only one study and could not be compared. Conclusion: There is a need for further experiments in the area, in order to establish the best form of purification and the identification of the substrate with higher anti-fatigue activity.
References
Bai, N.; He, K.; Roller, M.; Lai, C.S.; Bai, L.; Pan, M.H. Flavonolignans and other constituents from Lepidium meyenii with activities in anti-inflammation and human cancer cell lines. Journal of Agricultural and Food Chemistry. Vol. 63. Num. 9. 2015. p. 2458-2463.
Conlee, R.K. Muscle glycogen and exercise endurance: A twenty-year perspective. Exercise and Sport Sciences Reviews. Provo. Vol. 15. Num. 1. 1987. p. 1-28.
Davis, J.M.; Bailey, S.P. Possible mechanisms of central nervous system fatigue during exercise. Medicine Science in Sports & Exercise. Columbia. Vol. 29. Num. 1. 1997. p. 45-57.
Fitts, R.H. Cellular mechanisms of fatigue muscle. Physiological Reviews. Milwaukee. Vol. 74. Num. 1. 1994. p. 49-93.
Green, H.J. Mechanisms of muscle fatigue in intense exercise. Journal of Sports Sciences. Ontario. Vol. 15. Num. 3. 1997. p. 247-256.
He, Z.; Feng, Y.; Xu, L.F.; Sun, L.; Shi, L.; Chen, X.M. In vitro antioxidant activity of ethanol extract of maca (Lepidium meyenii Walpers) cultivated in Yunnan. Food Sciencie. Vol. 31. Num. 1. 2010. p. 39-43.
Li, Y.; Xin, Y.; Xu, F.; Zheng, M.; Xi, X.; Cui, X.; Cao, H.; Guo, H.; Han, C. Maca polysaccharides: extraction optimization, struturalfeatures and anti-fatigue activities.International Journal of Biological Macromolecules. 2018. p. 618-624
Li, J.; Sun, Q.; Meng, Q.; Wang, L.; Xiong, W.; Zhang, L. Anti-fatigue activity of polysaccharide fractions from Lepidium meyenii Walp (maca), Int. J. Boil. Macromol. Vol. 95. 2016. p. 1305-1311.
McLester, J.R. Muscle contraction and fatigue: The role of adenosine 5’-Diphosphate and inorganic phosphate. Sports Medicine. Tuscaloosa. Vol. 23. Num. 5. 1997. p. 287-305.
Sobrero, A.; Puglisi, F.; Guglielmi, A.; Belvedere, O.; Aprile, G.; Ramello, M.; Grossi, F. Fatigue: a main component of anemia symptomatology. Seminars Oncology. Udine. Vol. 28. Num. 8. 2001. p. 15-18.
Tanaka, M.; Nakamura, F.S.; Matsumura, A.; Nozaki, S.; Watanabe, Y. Establishment, and assessment of a rat model of fatigue. Neuroscience Letters. Vol. 352. Num. 3. 2003. p. 159-162.
Feng, C.X.; Yan, Y.L.; Min, J.C.; Ling, J.Z.; Le, C.S.;Wen, J.S.; Guang, M.L. Hypoxia Tolerance and Fatigue Relief Produced by Lepidium meyenii and its Water-soluble Polysaccharide in Mice.Food Science and Technology Research. 2016. p. 611-621.
Wang, Y.; Wang, Y.; McNeil, B.; Harvey, L.M. Maca: An Andean crop with multi-pharmacological functions. Food Research International. Beijing. Vol. 40. Num. 7. 2007. p. 783-792.
Westerblad, H.; Allen, D.G.; Lannergren, J. Muscle fatigue: lactic acid or inorganic phosphate the major cause? News in physiological sciences. Stockholm. Vol. 17. Num. 1. 2002. p. 17-21.
Tang, W.; Jin, L.; Xie, L.; Huang, J.; Wang, N.; Chu, B.; Dai, X.; Liu, Y.; Wang, R.; Zhang, Y. Structural Characterization and Antifatigue Effect In Vivo of Maca (Lepidium meyenii Walp) Polysaccharide.Journal of Food Science. 2016. p. 1-8.
Yang, Q.; Jin, W.; Lv, X.; Dai, P.; Ao, Y.; Wu, M. Effects of macamides on endurance capacity and anti-fatigue property in prolonged swimming mice. Pharmaceutical Biology. Vol. 54. Num. 5. 2016. p. 827-834.
Zunk, K.; Mummenhoff, K.; Hurka, H. Chloroplast DNA restriction site variation in the Brassicaceae tribe Lepidieae. Plant Molecular Evolution Newsletter. Vol. 3. 1993. p. 40-44.
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