Infections of the upper respiratory tract caused by physical exercise. Glutamine supplementation prevents this complication?

  • Alessandra Hellbrugge Centro Universitário São Camilo - Curso de Graduação em Nutrição
  • Fabio Henrique Ornellas Universidade Gama Filho / Professor de Imunofisiologia Programa de Pós-Graduação Lato Sensu. Instituto Brasileiro de Ensino e Pesquisa em Fisiologia do Exercí­cio
Keywords: Glutamine, Physical exercise, Imune system, Superior respiratory tract infection

Abstract

The athlete`s performance depends, among various events, adequate food and some situations, such as periods of intense training, account is also a nutritional supplement in order to guarantee performance. Glutamine is an amino acid important for the immune system cells, a decrease can leave the athlete more prone to infections. Considering these aspects, this paper aims to review existing literature about studies on the use of glutamine supplementation in prevention of infections of upper respiratory tract (URTI), caused by exercise, usually high intensity and long duration. These types of exercise produce changes in the count and function f some immune cells such as lymphocytes, T cells, B, Natural Killers, and inhibition of local production of IgA and a decrease in plasma glutamine concentration. This temporary immunosupression called “open window” can leave the athlete more prone to infections such as URTI. Studies indicate that supplementation with glutamine inhibits the fall of this amino acid in plasma, but does not maintain the levels of lymphocytes, neutrophils and secretion of IgA. Therefore, it is not possible to say that supplementation with glutamine is an effective method to reduce the incidence of URTI caused by physical exercise.

References

Antonio, J.; Street, C. Glutamine: a potenially useful supplement for athletes. Canadian Journal of Applied Physiology. Vol. 24. Num. 1. 1999. p. 1-14.

Brenner,I.K.M.; Shek, P.N.; Zamecnik, J.; Shephard, R.J. Stress humones and the immunological responses to heart and exercise. International Journal of Sports and Medicine.Vol. 19. 1998.p. 130-143.

Carcia, J.R.J.; Pithon-Curi, T.C; Curi, R. Conseqüências do exercício para o metabolismo da glutamina e função imune. Revista Brasileira de Medicina do Esporte. Vol. 6. 2000. p. 99-107.

Castell, L.M. Can Glutamine modify the apparent immunodepression observed after prolonged, exhaustive exercise? Nutrition. Vol. 18. 2002. p. 371-375.

Castell, L.M.; Poortmans, J.; Newsholme, E.A. Does glutamine gave a role in reducing infections in athletes? European Journal of Applied Physiology. Vol. 73. 1996. p. 488-490.

Cox, A.J; Gleeson, M.; Pyne, D.B.; Callister, R.; Hopkins, W.G.; Ficker, P.A. Clinical and laboratory evaluation of upper respiratory symptoms in elite athletes. Clinical Journal of Sport Medicine. Vol. 18 Num. 4. 2008. p. 438-445.

Cruzat, V.F.; Petry, E.R.; Tirapegui, J. Glutamina: Aspectos bioquímicos, matabolicos, moleculares e suplementação. Revista Brasileirade Medicina do Esporte. Vol. 15. Num. 5. 2009. p. 392-397.

Daniel, J.F.; Cavaglieri, R.C. Efeitos da suplementação crônica de glutamina sobre a performance de atletas de futebol da categoria juvenil. Revista Brasileira de Ciencia E moimento. Vol. 13.Num. 4. 2005. p. 55-64.

Davis, J.M.; Murphy, E.A.; Brown, A.S.; Carmichael, M.D.; Ghaffar, A.; Mayer, E.P. Effects os moderate exercise and oat β-glucan on innate immune function and susceptibility to respiratory infection. American Journal of Physiology Regulatory, Integrative and Comparative Physiology. Vol. 286. 2004. p. 366-372.

Ekblom, B.; Ekblom, O.; Malm, C. Infectious episodes before and after a marathon race. Scandinavian Journal of Medicine and Science in sports.Vol. 16. 2006. p. 287-293.

Francisco, T.D.; Pithon-Curi, T.C.; Curi, R.; Garcia Junior, J.R. Glutamina:Metabolismo, destinos, funções e relação com o exercício físico. Arquivos de Ciência e Saúde da Unipar. Vol. 6. Num. 1. 2002. p. 81-88.

Gleesen, M.; Pyne, D.B. Exercise effects on mucosal immunity. Immunology and Cell Biology. Vol. 78. 2000. p. 536-544.

Hiscock, N.; Mackinnon, L.T. A comparison of plasma glutamine concentration in athletes from different sports. Medicine and Science in Sports and Exercise. Vol. 30. Num. 12. 1998. p. 1693-1696.

Kreider, R.B. Dietary supplements and the promotion of muscle growth with resistance exercise. Sports Medicine. Vol. 27. Num. 2. 1999. p. 97-110.

Krzywkowski, K.; Petersen, E.W.; Ostrowaki, K.; Kristensen, J.H.; Boza, J.; Pedersen, B.K. Effect of glutamine supplementation on exercise-induced changes in lymphocyte function. American Journal of physiology-cell physiology. Vol. 281. 2001. P. 1259-1265.

Leandro, C.G.; Nascimento, E.; Azevedo, M.M.; Viegas, A.; Albuquerque, C.; Cavalcanti, C.B.; Manhães-de-castro, R.; Castro, C.M.M.B. Effect of glutamine on the number of blood leukocytes and on the phagocytic function of macrophages of stressed rats.Revista de Nutrição. Vol. 19. Num. 4. 2006. p. 437-444.

Matthews, C.E.; Ockene, I.S.; Freedson, P.S.; Rosal, M.C.; Merriam, P.A.; Herbert, J.R. Moderate to vigorous physical activity and risk of upper-respiratorytract infection. Medicine and science in Sports and Exercise. Vol. 34. Num. 8. 2002. p. 1242-1248.

Nascimento, E.; Leandro, C.V.G.; Amorim, M.A.F.; Palmeira, A.; Ferro, T.C.; Castro, C.M.M.B.; Castro, R.M. Effect of acute restraint stress, chronic swim stress and glutamine administration on the release of superoxide from alveolar macrophages of rats. Revista de Nutrição. Vol. 20. Num. 4. 2007. p. 387-396.

Nieman, D.C. Exercise, upper respiratory tract infection, and the immune system. Medicine and Science in Sports and Exercise. Vol. 26. 1994. p. 28-39.

Novelli, M.; Strufaldi, M.B.; Rogero, M.M.; Rossi, L. Suplementação de glutamina aplicada à atividade física. Revista Brasileira de Ciência e Movimento. Vol. 15. Num. 1. 2007. p. 109-117.

O’Flaherty, L.; Bouchier-Hayes, D.J. Immunonutrition and surgical practice. Proceedings of the nutrition Society. Vol. 58. 1999. p. 831-837.

Pedersen, B.K.; Bruunsgaard, H.; Jensen, M.; Toft, A.D.; Hansen, H.; Ostrowski, K. Exercise and immune system–influence of nutrition and ageing. Journal of Science and Medicine in Sport. Vol. 2. 1999. p. 234-252.

Pedersen, B.K.; Hoffman-Goetz, L. Exercise and the immune system: Regulation, integration, and adaptation. Physiological Reviews. Vol. 80. Num. 8. 2000. p. 1056-1073.

Pedersen, B.K.; Toft, A.D. Effects of exercise on lymphocytes and cytokines. British Journal of Sports Medicine. Vol. 34. 2000. p.246-251.

Pithon-Curi, T.C.; Levada, A.C.; Lopes, L.R.; Doi, S.Q.; Curi, R. Glutamine plays a role in superoxide production and the expression of p47phox, p22phox and gp91phox in rat neutrophils. Clinical Science. Vol. 103. Num. 4. 2002. p. 403-408.

Reid, V.L.; Gleeson, M.; Williams, N.; Clancy, R.L. Clinical investigation of athletes with persistent fatigue and/or recurrent infection. British Journal of Sports Medicine. Vol. 38. 2004. p. 42–45.

Rogero, M.M.; Tirapegui, J. Aspectos nutricionais sobre glutamina e atividade física. Revista Nutrire. Vol. 25. 2003. p. 99-124.

Rogero, M.M.; Tirapegui, J.; Pedrosa, R.G.; Castro, I.A.; Pires, I.S.O. Effect of alanyl-glutamine supplementation on plasma na tissue glutamine concentrations in rats submitted to exhaustive exercise. Nutrition. Vol. 22. 2005.p. 564-571.

Rogero, M.M.; Tirapegui, J.; Pedrosa, R.G.; Pires, I.S.O.; Castro, I.A. Plasma and tissue glutamine response to acute and chronic supplementation with L-glutamine and L-alanyl-glutamine in rats. Nutrition Research. Vol. 24. 2004. p. 261-270.

Rohde, T.; Asp, S.; Maclean, D.A.;Pedersen, B.K. Competitive sustained exercise in humans, lynphokine activated killer cell activity, and glutamine-an intervention study. European Journal of Applied physiology and Occupational physiology. Vol. 78. 1998. P. 448-453.

Romano, L.; Borges, I.P. A suplementação de glutamina não reverte a imunossupressão induzida pelo exercício. Revista Brasileira de Prescrição e Fisiologia do Exercício. Vol 1. Num. 1. 2007. p. 65-78.

Rowbotton, D.G.; Keast, D.; Goodman, C.; Morton, A.R. The haematological, biochemical and immunological profile of athletes suffering from the overtraining syndrome. European Journal of Applied Physiology. Vol. 70. 1995. p. 502-509.

Santos, R.V.T.; Caperuto, E.C.; Costa Rosa, L.F.B.P. Effects os acute exhaustive physical exercise upon glutamine metabolismo of lymphocytes from trained rats. Life Sciences. Vol. 80. 2007. p. 573-578.

Shephard, R.J. Overview of the epidemiology of exercise immunology. Immunology and Cell Biology. Vol. 78. 2000. p. 485-495.

Walsh,N.P.; Blannin, A.K.; Bishop, N.C.; Robson, P.J.; Gleeson, M. Effect of oral glutamine supplementation on human neutrophil lipopolysacharide-stimulated degranulation following prolonged exercise. International Journal of Sport Nutrition and Exercise Metabolism. Vol. 10. 2000. p. 39-50.

Weidner, T.G. Reporting behaviors and activity levels of intercollegiate athletes with na URI. Medicine Science of Sports Exercise. Vol. 26. 1994. p. 22-27.

Wray, C.J.; Mammen, J.M.V.; Hasselgren, P. Catabolic response to stress and potential benefits of nutrition support. Nutrition. Vol. 18. 2002. p. 971-977.

Wu, G.; Meininger, C.J.; Knabe, D.A.; Bazer, F.W.; Rhoads, J.M. Arginine nutrition in development, health and disease. Current Opinion in Clinical Nutrition and Metabolic Care. Vol. 3. 2000. p. 59-66.

Ziegler, T.R.; Benfell, K.; Smith, R.J. Safety and metabolic effects of L-glutamine administration in humans. Journal of Parenteral and Enteral Nutrition. Vol. 14. 1990. p. 137-146.

Published
2012-01-13
How to Cite
Hellbrugge, A., & Ornellas, F. H. (2012). Infections of the upper respiratory tract caused by physical exercise. Glutamine supplementation prevents this complication?. RBNE - Brazilian Journal of Sports Nutrition, 4(19). Retrieved from https://www.rbne.com.br/index.php/rbne/article/view/162
Section
Scientific Articles - Original