Nitrate derived from beet juice and its influences on high-intensity exercise: a systematic review of randomized clinical trials
Abstract
Nitrate (NO3) supplementation through beetroot juice seems effective in high-intensity and short-duration exercises, which primarily use the anaerobic metabolic pathway. In order to clarify these issues, a systematic review was developed to investigate the effects of the use of NO3 supplementation derived from sugar beet on performance. The search was performed in PubMed (via MedLine), Cochrane Library, and EMBASE using the search strategy: “Athletic Performances” OR “Sports” OR “Performance” AND “Nitrates” OR “Beta vulgaris” OR “Beet”. The primary study population should include healthy, physically active adults aged 18 to 65 years. The intervention with NO3- should be beetroot juice and controlled with placebo intervention, with characteristics similar to beetroot juice and depleted in NO3. The studies should bring as outcome variables of physical performance in exercises with a predominantly anaerobic metabolic pathway. We consider single or double-blind, randomized clinical trials. 177 articles were found in the databases, which after the screening and eligibility stages, only 9 remained in the sample. The intervention with NO3 from beet juice showed essential contributions in the performance tests of the primary studies. Most of the included trials showed better results in the group that ingested NO3. It can conclude that NO3 from beetroot juice is an essential ergogenic resource in high intensity and short duration activities, and, therefore, it can be used in conditions that aim to increase the performance of athletes.
References
-Benjamim, C.J.R.S.; Júnior, F.W.; Figueirêdo, M.Í.L.S.; Benjamim, C.J.R.; Cavalcante, T.C.F.; Silva, A.A.M.; Monteiro, L.R.L.; Santana, M.D.R.; Garner, D.M.; Valenti, V.E. Beetroot (beta vulgaris L.) extract acutely improves heart rate variability recovery following strength exercise: A randomized, double-blind, placebo-controlled crossover trial-pilot study. Journal of the American College of Nutrition. Vol. 40. num. 4. 2021. p. 307-316.
-Cochran, A.J.R.; Percival, M.E.; Tricarico, S.; Little, J.P.; Cermak, N.; Gillen, J.B.; Tarnopolsky, M.A.; Gibala, M.J. Intermittent and continuous high-intensity exercise training induce similar acute but different chronic muscle adaptations: Muscle adaptations to high-intensity exercise training. Experimental Physiology. Vol. 99. Num. 5. 2014. p. 782-791.
-Cuenca, E.; Jodra, P.; Pérez-López, A.; González-Rodríguez, L.G.; Fernandes da Silva, S.; Veiga-Herreros, P.; Domínguez, R. Effects of beetroot juice supplementation on performance and fatigue in a 30-s all-out sprint exercise: A randomized, double-blind cross-over study. Nutrients. Vol. 10. Num. 9. 2018.
-Domínguez, R.; Garnacho-Castaño, M.V.; Cuenca, E.; García-Fernández, P.; Muñoz-González, A.; Jesús, F.; Lozano-Estevan, M.D.C.; Fernandes da Silva, S.; Veiga-Herreros, P.; Maté-Muñoz, J.L. Effects of beetroot juice supplementation on a 30-s high-intensity inertial cycle ergometer test. Nutrients. Vol. 9. Num. 12. 2017.
-Domínguez, R.; Maté-Muñoz, J.L.; Cuenca, E.; García-Fernández, P.; Mata-Ordoñez, F.; Lozano-Estevan, M.C.; Veiga-Herreros, P.; Silva, S.F.; Garnacho-Castaño, M.V. Effects of beetroot juice supplementation on intermittent high-intensity exercise efforts. Journal of the International Society of Sports Nutrition. Vol. 15. Num. 2. 2018.
-Gao, C.; Gupta, S.; Adli, T.; Hou, W.; Coolsaet, R.; Hayes, A.; Kim, K.; Pandey, A.; Gordon, J.; Chahil, G.; Belley-Cote, E.P.; Whitlock, R.P. The effects of dietary nitrate supplementation on endurance exercise performance and cardiorespiratory measures in healthy adults: a systematic review and meta-analysis. Journal of the International Society of Sports Nutrition. Vol. 18. Num. 1. 2021.
-Hernández, A.; Schiffer, T.A.; Ivarsson, N.; Cheng, A.J.; Bruton, J.D.; Lundberg, J.O.; Weitzberg, E.; Westerblad, H. Dietary nitrate increases tetanic [Ca2+]i and contractile force in mouse fast-twitch muscle: Dietary nitrate and contractile function. The journal of physiology. Vol. 590. Num. 15. 2012. p. 3575-3583.
-López-Samanes, Á.; Pérez-López, A.; Moreno-Pérez, V.; Nakamura, F.Y.; Acebes-Sánchez, J.; Quintana-Milla, I.; Sánchez-Oliver, A.J.; Moreno-Pérez, D.; Fernández-Elías, V.E.; Domínguez, R. Effects of beetroot juice ingestion on physical performance in highly competitive tennis players. Nutrients. Vol. 12. Num. 2. 2020.
-MacInnis, M.J.; Gibala, M.J. Physiological adaptations to interval training and the role of exercise intensity. The Journal of Physiology. Vol. 595. Num. 9. 2017. p. 2915-2930.
-McMahon, N.F.; Leveritt, M.D.; Pavey, T.G. The effect of dietary nitrate supplementation on endurance exercise performance in healthy adults: A systematic review and meta-analysis. Sports Medicine. Vol. 47. Num. 4. 2017. p. 735-756.
-Mosher, S.L.; Sparks, S.A.; Williams, E.L.; Bentley, D.J.; Mc Naughton, L.R. Ingestion of a nitric oxide enhancing supplement improves resistance exercise performance. Journal of strength and conditioning research. Vol. 30. Num. 12. 2016. p. 3520-3524.
-Nyakayiru, J.; Jonvik, K.L.; Trommelen, J.; Pinckaers, P.J.M.; Senden, J.M.; Van Loon, L.J.C.; Verdijk, L.B. Beetroot juice supplementation improves high-intensity intermittent type exercise performance in trained soccer players. Nutrients. Vol. 9. Num. 3. 2017.
-Nyberg, M.; Christensen, P.M.; Blackwell, J.R.; Hostrup, M.; Jones, A.M.; Bangsbo, J. Nitrate-rich beetroot juice ingestion reduces skeletal muscle O2 uptake and blood flow during exercise in sedentary men. The Journal of Physiology. 2021
-Ranchal-Sanchez, A.; Diaz-Bernier, V.M.; De La Florida-Villagran, C.A.; Llorente-Cantarero, F.J.; Campos-Perez, J.; Jurado-Castro, J.M. Acute effects of beetroot juice supplements on resistance training: A randomized double-blind crossover. Nutrients. Vol. 12. Num. 7. 2020.
-Rojas-Valverde, D.; Montoya-Rodríguez, J.; Azofeifa-Mora, C.; Sanchez-Urena, B. Effectiveness of beetroot juice derived nitrates supplementation on fatigue resistance during repeated-sprints: a systematic review. Critical reviews in food science and nutrition. Vol. 61. Num. 20. 2021. p. 3395-3406.
-Shannon, O.M.; Barlow, M.J.; Duckworth, L.; Williams, E.; Wort, G.; Woods, D.; Siervo, M.; O’Hara, J.P. Dietary nitrate supplementation enhances short but not longer duration running time-trial performance. European journal of applied physiology. Vol. 117. Num. 4. 2017. p. 775-785.
-Thompson, C.; Vanhatalo, A.; Jell, H.; Fulford, J.; Carter, J.; Nyman, L.; Bailey, S.J.; Jones, A.M. Dietary nitrate supplementation improves sprint and high-intensity intermittent running performance. Nitric oxide: Biology and chemistry. Vol. 61. 2016. p. 55-61.
-Wylie, L.J.; Bailey, S.J.; Kelly, J.; Blackwell, J.R.; Vanhatalo, A.; Jones, A.M. Influence of beetroot juice supplementation on intermittent exercise performance. European journal of applied physiology. Vol. 116. Num. 2. 2016. p. 415-425.
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