The importance of a dietary intervention and physical activity in modulation of IGF-I in olders with sarcopenia
Abstract
The aging process is associated to muscle mass loss, partly responsible for the decline of the skeletal muscle mass and strength, which contributes to the increase of the number of falls in elderly population. The fragility of the elderly with sarcopeniaaffects their mobility and life quality, increasing the risk of falls and the use of resources for health care. GH and IGF-1 levels are important mediators in protein synthesis and muscle mass formation, and decrease with aging. Physical activity and a healthy diet are the best ways of neutralizing the sarcopeniaand other aspects of the aging process. Elderly population reduces the food intake, increasing the need for protein, therefore, creating a barrier to obtain all the benefits of strength training related to sarcopenia. The strength training also increases significantly the demand of energy, the action of insulin and the increase of IGF-1 levels. The link between sarcopeniaand physical inability among the elderly shows the need for further research in the development of more effective interventions in order to prevent or, at least, partially reverse sarcopenia.
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