Influence of nitrate intake on cardiovascular and hemodynamic responses and performance to strength training: a critical review
Abstract
Introduction: Nitrate is a nutritional resource used in sports due to its ergogenic activity, being a precursor substance of nitric oxide and having an important role in the regulation of functional and physiological parameters related to sports performance, due to its vasodilator and hypotensive action. Objective: To carry out a literature review to present and discuss the effects of nitrate ingestion on cardiovascular and hemodynamic responses during strength training. Materials and Methods: A search was carried out in the PubMed and SciELO databases, including studies that associated these three factors (nitrate; cardiovascular responses; strength training). Results: It was possible to verify that nitrate influences the hemodynamic response due to the metabolization of nitrate, which will generate nitric oxide as a product in the systemic circulation, increasing its production in the bloodstream, especially in conditions where there is an increased demand for oxygen, such as during physical exercise. The physiological effects include the improvement of mitochondrial and muscle breathing, modifying factors such as blood pressure, heart rate and reduction of oxygen consumption during exercise, due to smooth muscle relaxation, promoting vasodilation and blood flow regulation. and consequently improving the supply of oxygen. Conclusion: Nitrate supplementation has positive physiological effects in training that improve performance and sports performance. However, these effects are not seen in all studies, due to the influence of certain variables such as physical conditioning, exercise duration and administered doses.
References
-Alvim, R.O.; Santos, P.C.J.L.; Bortolotto, L.A.; Mill, JG, Pereira A C. Arterial Stiffness: Pathophysiological and Genetic Aspects. International Journal of Cardiovascular Sciences. Vol. 30. Num. 5. 2017. p. 433-441. Disponível em: https://doi.org/10.5935/2359-4802.20170053
-Bailey, S.J.; Winyard, P.; Vanhatalo, A.; Blackwell, J.R.; Dimenna, F.J.; Wilkerson D.P.; Tarr, J.; Benjamin, N.; Jones, A.M. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. Journal of Applied Physiology. Vol. 107. Num. 4. 2009. p. 1144-1155. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/19661447/>
-Bahadoran, Z.; Mirmiran, P.; Kabir, A.; Azizi, F.; Ghasemi, A. The Nitrate-Independent Blood Pressure-Lowering Effect of Beetroot Juice: A Systematic Review and Meta-Analysis. Advances in Nutrition. Vol. 8. Num. 6. 2017. p. 930-938. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/29141968/>
-Bescós, R.; Rodríguez, F.A.; Iglesias, X.; Ferrer, M.D.; Iborra, E.; Pons, A. Acute administration of inorganic nitrate reduces VO(2peak) in endurance athletes. Medicine & Science in Sports & Exercise. Vol. 43. Num. 10. 2011. p. 1979-1986. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/21407132/>
-Burke, L.M.; Castell, L.M.; Casa, D.J.; Close, G.L.; Costa, R.J.S.; Desbrow, B.; Halson, S.L.; Lis, D.M.; Melin, A.K.; Peeling, P.; Saunders, P.U.; Slater, G.J.; Sygo, J.; Witard, O.C.; Bermon, S.; Stellingwerff, T. International Association of Athletics Federations Consensus Statement 2019: Nutrition for Athletics. International Journal of Sport Nutrition and Exercise Metabolism. Vol. 29. Num. 2. 2019. p. 73-84. Disponível em <https://pubmed.ncbi.nlm.nih.gov/30952204/>
-Calvo, J.L.; Alorda-Capo, F.; Pareja-Galeano, H.; Jiménez, S.L. Influence of Nitrate Supplementation on Endurance Cyclic Sports Performance: A Systematic Review. Nutrients. Vol. 12. Num. 6. 2020. p. 1796. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/32560317/>
-Chiba, T.; Sakuma, K.; Komatsu, T.; Cao, X.; Aimoto, M.; Nagasawa, Y.; Shimizu, K.; Takahashi, M.; Hori, Y.; Shirai, K.; Takahara, A. Physiological role of nitric oxide for regulation of arterial stiffness in anesthetized rabbits. Journal of Pharmacological Sciences. Vol. 139. Num. 1. 2019. p.42-45. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/30528468/>
-Cuenca, E.; Jodra, P.; Pérez-López, A.; González-Rodríguez, L.G.; Fernandes da Silva, S.; Veiga-Herreros, P.; Domínguez R. Effects of Beetroot Juice Supplementation on Performance and Fatigue in a 30-s All-Out Sprint Exercise: A Randomized, Double-Blind Cross-Over Study. Nutrients. Vol. 10. Num. 9. 2018. p 1222. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/30181436/>
-Domínguez, R.; Cuenca, E.; Maté-Muñoz, J.L.; García-Fernández, P.; Serra-Paya N.; Estevan, M.C.; Herreros, P.V.; Garnacho-Castaño, M.V. Effects of Beetroot Juice Supplementation on Cardiorespiratory Endurance in Athletes. A Systematic Review. Nutrients. Vol. 9. Num. 1. 2017. p. 43. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/28067808/>
-Ferreira, L.P.; Moreira, O.C.; Caldas, L.R.R.; Rezende, L.M.T.; Hughes, K.; Souza, E.O.; Carneiro Junior, M.A. Cardiovascular responses of beginner and advanced practitioners to different volume and intensity resistance exercise protocols. European Journal of Human Movement. Vol. 44. 2020. p. 80-94.
-Fernández-Lázaro, D.; Díaz, J.; Caballero, A.; Córdova, A. The training of strength-resistance in hypoxia: effect on muscle hypertrophy. Biomédica. Vol. 39. Num. 1. 2019. p. 212-220.
-Guerra, C.V., Soares, B.E.S., Morais, F.M.A. de O.; Porto, A.A.; Benjamim, C.J.R. Nitrato derivado do suco de beterraba e suas influências no exercício de alta intensidade: uma revisão sistemática de ensaios clínicos randomizados. Revista Brasileira De Nutrição Esportiva. São Paulo. Vol. 16. Num. 97. 2022. p. 107-117. Disponível em: <http://www.rbne.com.br/index.php/rbne/article/view/1975>
-Ivy J.L. Inorganic Nitrate Supplementation for Cardiovascular Health. Methodist Debakey Cardiovasc Journal. Vol. 15. Num. 3. 2019. p. 200-206. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/31687099/>
-Jones, A.M.; Dietary nitrate supplementation and exercise performance. Sports Medicine. Vol. 44. Num. 1. 2014. p. 35-45. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/24791915/>
-Jones A.M.; Vanhatalo, A.; Seals, D.R.; Rossman, M.J.; Piknova, B.; Jonvik, K.L. Dietary Nitrate and Nitric Oxide Metabolism: Mouth, Circulation, Skeletal Muscle, and Exercise Performance. Medicine & Science in Sports & Exercise. Vol. 53. Num. 2. 2021. p. 280-294. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/32735111/>
-Jurado-Castro, J.M.; Campos-Perez, J.; Ranchal-Sanchez, A.; Durán-López, N.; Domínguez, R. Acute Effects of Beetroot Juice Supplements on Lower-Body Strength in Female Athletes: Double-Blind Crossover Randomized Trial. Sports Health. Vol. 14. Num. 6. 2022. p. 812-821. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/35603411/>
-Larsen, F.J.; Weitzberg, E.; Lundberg, J.O.; Ekblom, B. Effects of dietary nitrate on oxygen cost during exercise. Acta Physiologica. Vol. 191. Num. 1. 2007. p. 59-66. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/17635415/>
-Larsen, F.J.; Weitzberg, E.; Lundberg, J.O.; Ekblom, B. Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise. Free Radical Biology and Medicine. Vol. 48. Num. 2. 2010. p. 342-347. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/19913611/>
-Larsen, F.J.; Schiffer, T.A.; Borniquel, S.; Sahlin, K.; Ekblom, B.; Lundberg, J.O.; Weitzberg, E. Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metabolism. Vol. 13. Num. 2. 2011. p. 149-159. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/21284982/>
-Lowings, S.; Shannon, O.M.; Deighton, K.; Matu, J.; Barlow, M.J. Effect of Dietary Nitrate Supplementation on Swimming Performance in Trained Swimmers. International Journal of Sport Nutrition and Exercise Metabolism. Vol. 27. Num. 4 2017. p. 377-384. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/28182502/>
-Lundberg, J.O.; Weitzberg, E.; Gladwin, M.T. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nature Reviews Drug Discovery. Vol. 7. Num. 2. 2008. p. 156-167. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/18167491/>
-Macuh, M.; Knap, B. Effects of Nitrate Supplementation on Exercise Performance in Humans: A Narrative Review. Nutrients. Vol. 13. Num. 9. 2021. p. 3183. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/34579061/>
-McMahon, N.F.; Leveritt, M.D.; Pavey, T.G. The Effect of Dietary Nitrate Supplementation on Endurance Exercise Performance in Healthy Adults: A Systematic Review and Meta-Analysis. Sports Medicine. Vol. 47. Num. 4. 2017. p. 735-756. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/27600147/>
-Moreira, O.C.; Faraci, L.L.; Matos, D.G.; Mazini Filho, M.L.; Silva, S.F.; Aidar, F.J.; Hickner, R.C.; de Oliveira, C.E. Cardiovascular Responses to Unilateral, Bilateral, and Alternating Limb Resistance Exercise Performed Using Different Body Segments. Journal of Strength and Conditioning Research. Vol. 31. Num. 3. 2017. p. 644-652. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/26382128/>
-Moreira, O.C.; Oliveira, C.E.P.; Matos, D.G.; Silva, S.F.; Hickner, R.C; Aidar, F.J. Cardiovascular response to strength training is more affected by intensity than volume in healthy subjects. Revista Andaluza de Medicina Del Deporte. Vol. 11. 2018. p. 1-5. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1888754617300278>
-Ocampo, D.A.; Paipilla, A.F.; Marín, E.; Vargas-Molina, S.; Petro, J.L; Pérez-Idárraga, A. Dietary Nitrate from Beetroot Juice for Hypertension: A Systematic Review. Biomolecules. Vol. 8. Num. 4. 2018. p. 134. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/30400267/>
-Omar, S.A.; Webb, A.J.; Lundberg, J.O.; Weitzberg, E. Therapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases. Journal of Internal Medicine. Vol. 279. Num. 4. 2015. p. 315-336. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/26522443/>
-San Juan, A.F.; Dominguez, R.; Lago-Rodríguez, Á.; Montoya, J.J.; Tan, R.; Bailey, S.J. Effects of Dietary Nitrate Supplementation on Weightlifting Exercise Performance in Healthy Adults: A Systematic Review. Nutrients. Vol. 12. Num 8. 2020. p. 2227. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/32722588/>
-Senefeld, J.W.; Wiggins, C.C.; Regimbal, R.J.; Dominelli, P.B.; Baker, S.E.; Joyner, M.J. Ergogenic Effect of Nitrate Supplementation: A Systematic Review and Meta-analysis. Medicine & Science in Sports & Exercise. Vol. 52. Num. 10. 2020. p. 2250-2261. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/32936597/>
-Tan, R.; Cano, L.; Lago-Rodríguez, Á.; Domínguez, R. The Effects of Dietary Nitrate Supplementation on Explosive Exercise Performance: A Systematic Review. Int J Environ Res Public Health. Vol. 19. Num. 2. 2022. p. 762. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/35055584/>
-Thompson, K.G.; Turner, L.; Prichard, J.; Dodd, F.; Kennedy, D.O.; Haskell, C. Blackwell, J.R.; Jones, A.M. Influence of dietary nitrate supplementation on physiological and cognitive responses to incremental cycle exercise. Respiratory Physiology & Neurobiology. Vol. 193. Num. 1. 2014. p. 11-20. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/24389270/>
-Umbrello, M.; Dyson, A.; Feelisch, M.; Singer, M. The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching. Antioxidants & Redox Signaling. Vol. 19. Num. 14. 2013. p. 1690-1710.
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