Effect of HMB supplementation and resistance training in the treatment of cancer cachexia
Abstract
Introduction: The syndrome of cachexia is a frequent complication in patients with a malignancy in an advanced state and is a major cause of death. Objective: Given several existing strategies, we propose in this review to analyze effects of resistance training and supplementation of HMB as proposed subterfuge cachexia caused by unintentional weight loss triggered by metabolic imbalance in patients withtumors characterized by hypercatabolism. Literature Review: The physiological disturbances triggered by a session of resistance training increases the rates of protein synthesis in skeletal muscle tissue leading to significant gains in lean body mass and preventing proteolysis. What we find in this review suggests that HMB may inhibit the pathway of ubiquitin-proteasome proteolytic degradation of proteins responsible for and can inhibit specific intracellular signaling pathways involving protein kinase C-alpha and decrease the concentration of cytoplasmic nuclear factor -kappa B free. Conclusion: In view of various existing strategies in this review we propose a different view to what they propose to a cancer patient, to use the resistance training and eating a hmb as adjuvant therapy in order to restore the search for quality of life the patient.
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