Effects of glutamine supplementation on exercise: systematic review
Abstract
The glutamine is the amino acid more abundant in skeletal muscle and its use is essential for various body cells. Due too its plasma and tissue concentration are decreased after prolonged exercise, suggests that supplementation with glutamine brings benefits for practice of exercises. This work aimed to show through a systematic review the effects of glutamine supplementation in exercise. The articles search was performed using the keywords glutamine, supplementation and exercise, the following databases: U.S. National Library of Medicine (PubMed), Scientific Electronic Library Online (SciELO), Capes periodicals, Science Direct, Medigraphic, Google academic, University libraries. Were analyzed studies from 1998 to 2010, and 11 were used in the final sample. Most studies that evaluated the effect of glutamine on the immune system and improves performance found no significant effects. The studies evaluating the effects on gluconeogenesis, acid-basebalance and synthesis / degradation protein also found little effect. Thus, after analysis of studies, it was found that, although some studies have found benefits of glutamine supplementation, most observed little or no effect in the differents parameters evaluated.
References
-Araújo, A. C. M.; Soares, Y. N. G. Perfil de utilização de repositores protéicos nas academias de Belém, Pará. Revista de Nutrição. Campinas. Vol. 12. Num. 1. 1999. p. 5-19.
-Araújo, L. R.; Andreolo, J.; Silva, M. S. Utilização de suplemento alimentar e anabolizante por praticantes de musculação nas academias de Goiânia-GO. Revista Brasileira de Ciência e Movimento. Brasília. Vol. 10. Num. 3. 2002. p. 13-18.
-Bowtell, J. L.; e colaboradores. Effect of oral glutamine on whole body carbohydrate storage during recovery from exhaustive exercise. Journal of Applied Physiology. Vol. 86. Num. 6. 1999. p. 1770-1777.
-Bruce, M.; e colaboradores. Glutamine supplementation promotes anaplerosis but not oxidative energy delivery in human skeletal muscle. American Journal of Physiology –Endocrinology and Metabolism. Vol. 280. 2001. p. E669-E675.
-Candow, D. G.; e colaboradores. Effect of glutamine supplementation combined with resistance training in young adults. European Journal of Applied Physiology. Vol. 86. Num. 2. 2001. p. 142-149.
-Castell, L. M.; Newsholme, E. A. The effect of oral glutamine supplementation on athletes after prolonged, exhaustive exercise. Nutrition. Vol. 13. Num. 7. 1997. p. 738-742.
-Cruzat, V. F.;e colaboradores. Aspectos atuais sobre estresse oxidativo, exercícios físicos e suplementação. Revista Brasileira de Medicina no Esporte. Vol. 13. Num. 5. 2007. p. 336-342.
-Cruzat, V. F.; Alvarenga, M. L.; Tirapegui, J. Metabolismo e suplementação com glutamina no esporte. Revista Brasileira de Nutrição Esportiva. Vol. 4. Num. 21. 2010. p. 242-253.
-Cruzat, V. F.; Rogero, M. M.; Tirapegui, J. Effects of supplementation with free glutamine and the dipeptide alanyl-glutamine on parameters of muscle damage and inflammation in rats submitted to prolonged exercise. Cell Biochemistry and Function. Vol. 28. Num 1. 2010. p. 24–30.
-Daniel, J. F.; Cavaglieri, C. R. Efeitos da suplementação crônica de glutamina sobre a performance de atletas de futebol da categoria juvenil. Revista Brasileira de Ciência e Movimento. Vol. 13. Num. 4. 2005. p. 55-64.
-Favano, A.; e colaboradores. Peptide glutamine supplementation for tolerance of intermittent exercise in soccer players. Clinics. Vol. 63. Num. 1. 2008. p. 27-32.
-Finn, K. J.; Lund, R.; Rosene-Treadwell, M. Glutamine supplementation did not benefit athletes during short-term weight reduction. Journal of Sports Science and Medicine. Vol. 2. 2003. p. 163-168.
-Fontana, K. E. Efeito do exercícioresistido associado a suplementaçãode creatina ou glutamina na potência anaeróbia. Revista Brasileira de Ciência e Movimento. Vol. 14. Num. 3. 2006. p. 79-86.
-Fontana, K. E.; Valdes, H.; Baldissera, V. Glutamina como suplemento ergogênico. Revista Brasileira de Ciência e Movimento. Vol. 11. Num. 3. 2003. p. 91-96.
-GarciaJunior, J. R.; Pithon-Curl, T. C.; Curi, R. Consequências do exercício para o metabolismo da glutamina e função imune. Revista Brasileira de Medicina do Esporte. Vol. 6. Num. 3. 2000. p. 99-107.
-Gleeson, M.; Bishop, N. C. Modification of immune responses to exercise by carbohydrate, glutamine and anti-oxidant supplements. Immunology and Cell Biology. Vol. 78. 2000.p. 554-561.
-Hammarqvist, F.; e colaboradores. Alanyl-glutamine counteracts the depletion of free glutamine and the postoperative decline in protein synthesis in skeletal muscle. Annals of Surgery. Vol. 212. Num. 5. 1990. p. 637-644.
-Hankard, R. G.; Haymond, M. W.; Darmaun, D. Effect of glutamine on leucine metabolism in humans. American Journal of Physiology –Endocrinology and Metabolism. Vol. 271. 1996. p. E748-E754.
-Haub, M. D.;e colaboradores. Acute L-glutamine ingestion does not improve maximal effort exercise. The Journal of Sports Medicine and Physical Fitness. Vol. 38. Num. 3. 1998. p. 240-244.
-Heikkinen, A.; e colaboradores. Use of dietary supplements in Olympic athletes is decreasing: a follow-up study between 2002 and 2009. Journal of the International Society of Sports Nutrition. Vol. 8. Num. 1. 2011.
-Hellbrugge, A.; Ornellas, F. H. Infecções do trato respiratório superior causadas pelo exercício físico. A suplementação com glutamina previne esta complicação? Revista Brasileira de Nutrição Esportiva. Vol. 4. Num. 19. 2010. p. 36-43.
-Hiscock, N.; e colaboradores. Glutamine supplementation further enhances exercise-induced plasma IL-6. Journal of Applied Physiology. Vol. 95. 2003. p. 145-148.
-Hoffman, J. R.; e colaboradores. Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exercise. Journal of the International Society of Sports Nutrition. Vol. 7. Num. 8. 2010.
-Insúa, M. F.; Fuks, K. Síntesis proteica y glutamina. Revista digital. Buenos Aires. Num. 59. 2003.
-Iwashita, S.; e colaboradores. Impact of glutamine supplementation on glucose homeostasis during and after exercise. Journal of Applied Physiology. Vol. 99. 2005. p. 1858-1865.
-Kiehl, L. M. P. Efeitoda suplementação aguda de glutamina peptídeo e carboidrato em jogadores de futebol juniores: análise de parâmetros nutricionais, desempenho físico e bioquímicos. Tese de Doutorado. Faculdade de Medicina da Universidade de São Paulo. São Paulo. 2007.
-Krieger, J. W.; Crowe, M.; Blank, S. E. Chronic glutamine supplementation increases nasal but not salivary IgA during 9 days of interval training. Journal of Applied Physiology. Vol. 97. 2004. p. 585-591.
-Krzywkowski, K.; e colaboradores. Effect of glutamine supplementation on exercise-induced changes in lymphocyte function. American Journal of Physiology -Cell Physiology. Vol. 281. 2001a. p. C1259 –C1265.
-Krzywkowski, K.; e colaboradores. Effect of glutamine and protein supplementation on exercise-induced decreases in salivary IgA. Journal of Applied Physiology. Vol. 91. 2001b. p. 832-838.
-Liberali, R. Metodologia Científica Prática: um saber-fazer competente da saúde à educação. Florianópolis. Postmix. 2011. 206p.
-Maughan, R. J. Nutritional ergogenic aids and exercise performance. Nutrition Research Reviews. Vol. 12. 1999. p. 255-280.
-Newsholme, P.; e colaboradores. Glutamine and glutamate—their central role in cell metabolism and function. Cell Biochemistry and function. Vol. 21. 2003. p. 1-9.
-Novelli, M.; e colaboradores. Suplementação de glutamina aplicada à atividade física. Revista Brasileira de Ciência e Movimento. Vol. 15. Num. 1. 2007. p. 109-117.
-Oliver, A. J. S.; León, M. T. M.; Hernández, E. G. Estudio estadístico del consumo de suplementos nutricionales y dietéticos en gimnasios. Archivos LatinoAmericanos de Nutricion. Vol. 58. Num. 3. 2008. p. 221-227.
-Phillips, G. C. Glutamine: The Nonessential Amino Acid for Performance Enhancement. Current Sports Medicine Reports. Vol. 6. 2007. p. 265-268.
-Rogero, M. M.; Tirapegui, J. Aspectos nutricionais sobre glutamina e atividade física. Nutrire. Vol. 25. 2003. p. 87-112.
-Varnier, M.; e colaboradores. Stimulatory effect of glutamine on glycogen accumulation in human skeletal muscle. American Journal of Physiology –Endocrinology and Metabolism. Vol. 269. Num. 2. 1995. p. E309-E315.
-Williams, M. Dietary supplements and sports performance: amino acids. Journal of the International Society of Sports Nutrition. Vol. 2. Num. 2. 2005. p. 63-67.
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