Gutamine as ergogenic resource in practice of physical exercise
Abstract
Glutamine is the most abundant free amino acid in plasma and muscle tissue, but hyper catabolic situations may be classified as conditionally essential amino acid. The intense and prolonged exercise can reduce the plasma concentration of glutamine that is involved in various functions, such as proliferation and development of cells, acid balance, ammonia transportation between tissues, donation of carbon skeletons for gluconeogenesis and participation in antioxidant system. Glutamine is critical for the functionality of the immune system because it is the main precursor of energy and macromolecules into the lymphocyte. The aimwas to analyze published research in the last 10 years involving the influence of the use of glutamine supplementation on the immune system and performance inphysical exercise. Supplementation of glutamine combined with exercise has been effective in fighting infections, mainly the ITRS. The glutamine dipeptide supplement looks good alternative due to higher stability and the presence of gluconeogenic substrate, however, remains without scientific support effective in improving athletic performance, more research is needed to elucidate the ergogenic role of glutamine supplementation.
References
-Andreasen, A.S.; Pedersen-Skovsgaard, T.; Mortensen, O.H.; Van Hall, G.; Moseley, P.L.; Pedersen, B.K. The Effect of Glutamine Infusion on the Inflammatory Response and HSP70 during Human Experimental Endotoxaemia.Critical Care. Vol. 13. Num. 1. 2009. p. 1-8.
-Borges, B.D.B. A glutamina e o Exercício Físico. Monografia. Universidade de Franca. Franca. 2005.
-Cruzat, V.F.; Alvarenga, M.L.; Tirapegui, J. Metabolismo e Suplementação com Glutamina no Esporte. Revista Brasileira de Nutrição Esportiva. Vol. 4. Num. 21. 2010. p. 242-253. Disponível em: <http://www.rbne.com.br/index.php/rbne/article/view/185/181>
-Cruzat, V.F.; Petry, E.R.; Tirapegui, J. Glutamina: Aspectos Bioquímicos, Metabólicos, Moleculares e Suplementação. Revista Brasileira de Medicina do Esporte. Vol. 15. Num. 5. 2009. p. 392-397.
-Cruzat, V.F.; Rogero, M.M.; Borges, M.C.; Tirapegui, J. Aspectos Atuais sobre Estresse Oxidativo, Exercícios Físicos e Suplementação. Revista Brasileira de Medicina do Esporte. Vol. 13. 2007. p. 336-342.
-Curi, R.; Lagranha, C.J.; Doi, S.Q.; Sellitti, D.F.; Procopio, J.; Pithon-Curi, T.C.; Corless, M.; Newsholme P. Molecular Mechanisms of Glutamine Action. Journal of Cellular Physiology. Vol. 204. 2005. p. 392-401.
-Curyboaventura, M.F.; Levadapires, A.C.; Folador, A.; Albaloureiro, T.C.; Hirabara, S.M.; Peres, F.P.; Silva, P.R.; Curi, R.; Pithon-Curi, T.C. Effects of Exercise on Leukocyte Death: Prevention by Hydrolyzed Whey Protein Enriched with Glutamine Dipeptide. European JournalofApplied PhysiologyandOccupational Physiology. Vol. 103. Num. 3. 2008. p. 289-294.
-Daniel, J.F.; Cavaglieri, C.R. Suplementação de Glutamina e Resistência Imunológica em Atletas de Futebol. Saúde em Revista. Piracicaba. Vol. 7. Num. 17. 2005. p. 21-29.
-D'souza, R.; Tuck, J.P. Glutamine Supplements in the Critically ill. Journal of the Royal Society of Medicine. Vol. 97. 2004. p. 425-427.
-Favano, A.; Santos-Silva, P.R.; Nakano, E.Y.; Pedrinelli, A.; Hernandez, A.J.; Greve, J.M. Peptide Glutamine Supplementation for Tolerance of Intermittent Exercise in Soccer Players. Clinics. Vol. 63. Num. 1. 2008. p. 27-32.
-Glass, D.J. Signaling Pathways perturbing Muscle Mass. Current Opinionin Clinical Nutrition & Metabolic Care. Vol. 13. 2010. p. 225-229.
-Gleeson, M. Dosing and Efficacy of Glutamine Supplementation in Human Exercise and Sport Training. The Journal of Nutrition. Vol. 138. 2008. p. 2045S-2049S.
-Hellbrugge, A.; Ornellas, F.H. Infecções do Trato Respiratório Superior Causadas pelo Exercício Físico: Suplementação com Glutamina Previne esta Complicação? Revista Brasileira de Nutrição Esportiva. Vol. 4. Num. 19. 2010. p. 36-43.Disponível em: <http://www.rbne.com.br/index.php/rbne/article/view/162/160>
-Hoffman, J.R.; Ratamess, N.A.; Kang, J.; Rashti, S.L.; Kelly, N.; Gonzalez, A.M.; Stec, M.; Anderson, S.; Bailey, B.L.; Yamamoto, L.M.; Hom, L.L.; Kupchak, B.R.; Faigenbaum, A.D.; Maresh, C.M.Examination of the Efficacy of Acute L-alanyl-L-glutamine Ingestion During Hydration Stress in Endurance Exercise. Journal of the International Society of Sports Nutrition. Vol. 7. Num. 8. 2010. p. 2-12.
-Krieger, J.W.; Crowe, M.; Blank, S.E. Chronic Glutamine Supplementation Increases Nasal but not Salivary IgA during 9 days of Interval Training. JournalofApplied Physiology. Vol. 97. 2004. p. 585–591.
-Lagranha, C.J.; de Lima, T.M.; Senna, S.M.; Doi, S.Q.; Curi, R.; Pithon-Curi, T.C. The Effect of Glutamine Supplementation on the Functions of Neutrophils from Exercised Rats. Cell Biochemistry and Function. Vol. 23. 2005. p. 101–107.
-Lambertucci, A.C.; Lambertucci, R.H.; Hirabara, S.M.; Curi, R.; Moriscot, A.S.; Alba-Loureiro, T.C.; Guimarães-Ferreira, L.; Levada-Pires, A.C.; Vasconcelos, D.A.A.; Sellitti, D.F.; Pithon-Curi, T.C. Glutamine Supplementation Stimulates Protein-synthetic and Inhibits Protein-degradative Signaling Pathways in Skeletal Muscle of Diabetic Rats. PLoS One. Vol. 7. Num. 12. 2012. p. e50390.
-Liberali, R. Metodologia Científica Prática: Um Saber-fazer Competente da Saúde à Educação. Florianópolis. Postmix. 2011. p. 206.
-Moreira, A.; Kekkonen, R.A.; Delgado, L.; Fonseca, J.; Korpela, R.; Haahtela, T. Nutritional Modulation Ofexercise-induced Immunodepression in Athletes: A Systematic Review and Meta-analysis. European Journal of Clinical Nutrition. Vol. 61. 2007. p. 443-460.
-Nia, F.R.; Farzaneh, E.; Damirchi, A.; Majlan, A.S. Effect of L-glutamine Supplementation on Electromyographic Activity of the Quadriceps Muscle Injured by Eccentric Exercise. Iranian Journal of BasicMedical Sciences. Vol. 16. Num. 6. 2013. p. 808-812.
-Nicklin, P.; Bergman, P.; Zhang, B.; Triantafellow, E.; Wang, H.; Nyfeler, B.; Yang, H.; Hild, M.; Kung, C.; Wilson, C.; Myer, V.E.; MacKeigan, J.P.; Porter, J.A.; Wang, Y.K.; Cantley, L.C.; Finan, P.M.; Murphy, L.O. Bidirectional Transport of Amino Acids Regulates mTORand Autophagy. Cell. Vol. 136. Num. 3. 2009. p. 521-534.
-Nieman, D.C. Marathon Training and Immune Function. Sports Medicine. Vol. 37. Num. 45. 2007. p. 412-415.
-Nogiec, C.D.; Kasif, N. To Supplement or Not to Supplement: A Metabolic Network Framework for Human Nutritional Supplements. PLoS One. Vol. 8. Num. 8. 2013. p. e68751.
-Novelli, M.; Strufaldi, M.B.; Rogero, M.M.; Rossi, L. Suplementação de Glutamina aplicada à Atividade Física. Revista Brasileira de Atividade Física e Saúde. Vol. 15. Num. 1. 2007. p. 109-117.
-Pellegrinotti, I.L.; Cesar, M.C.; Rochelle, M.C.S.A.; Rochelle, S.L.A.; Borin, J.P.; Rosa, R.; Donatto, F.F.; Prestes, F.; Neto, J.B.; Cavaglieri, C.R. Efeito da Suplementação Oral de Glutamina na Performance de Nadadores de Meio fundo e Fundo. Revista Pensar a Prática. Vol. 15. Num. 2. 2012. p. 317-330.
-Peres, F.P. Efeitos da Suplementação de Glutamina Peptideo e Carboidratos na Performance de Triatletas de Alto Nível. Dissertação de Mestrado. Universidade Metodista de Piracicaba. Piracicaba. 2004.
-Rios, L.N.O.; Mendes, A.C.R.; Silva, V.S. Suplementação de Glutamina para Treinamento de Endurance. Revista de Educação Física/UNIJORGE. Vol. 1. Num. 1. 2011. p. 58-77.
-Rogero, M.M.; Tirapegui, J.; Pedrosa, R.G.; Pires, I.S.O.; Castro, I.A. Plasma and Tissue Glutamine Response to Acute and Chronic Supplementation with L-glutamine and L-alanyl-glutamine in Rats. Nutrition Research. Vol. 24. Num. 4. 2004. p. 261-270.
-Rogero, M.M.; Tirapegui, J.O.; Pedrosa, R.G.; Castro, I.A.; Pires, I.S.O. Effect of L-alanyl-L-glutamine Supplementation on the Plasma and Tissue Concentrations of Glutamine in Rats Submitted to Exhaustive Exercise. Nutrition. Vol. 22. 2006. p. 564-571.
-Simon,L.; Liberali, R. Efeitos da Suplementação de Glutamina no Exercício Físico: Revisão Sistemática. Revista Brasileira de Nutrição Esportiva. Vol. 6. Num. 33. 2012. p. 193-201. Disponível em: <http://www.rbne.com.br/index.php/rbne/article/view/300/303>
-Xi, P.; Jiang, Z.; Zheng, C.; Lin, Y.; Wu, G. Regulation of Protein Metabolism by Glutamine: Implications for Nutrition and Health. Frontiers in Bioscience. Vol. 16. 2011. p. 578-597.
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