Creatine supplementation and possible side effects

  • Marco Antonio de Queiroz Sousa Programa de pós-graduação em nutrição esportiva da Universidade Gama Filho - UGF. Especialização em fisiologia do exercí­cio (UNIFESP)
  • Carlos Humberto Gervazio de Azevedo Programa de pós-graduação em nutrição esportiva da Universidade Gama Filho - UGF. Graduado em Nutrição (UFPB)
Keywords: Creatine, Supplementation, Risk

Abstract

The creatine is a popular supplement used by professional athlete, amateurs, recess sports practioners, in an effort to increase in the muscle bigger fosfocreatine stocks to build and give extra energy in the form of adenosina trifosfato, aiming to increase the performance in exercises of high intensity and short duration. This study aim is to weigh the existing literature up under the possible effects of the creatine supplementation in the renal and liver function, gastrointestinal sintoms, cardiovascular effect and thermal exhaustion. A search of pubmed has been led to identify important articles using key words as: creatine, supplementation, risk. According to the existing literature the creatine supplement seems safe, when it is used by healthy adults in the recommended dosage (20g per day divided up in 5g during 5 days) and in the maintenance dosage (5g per day). In the subjects with renal disease history, gastrointestinal sintoms, the creatine can be associated to a greater risk to these diseases and sintoms. Therefore the creatine supplement safeness in children, pregnant and nursing women hasn’t been established. The lackness of side effects doesn’t mean safeness, it’s necessary researches that investigate the creatine supplementation effects in long term. And its prescription has to be done by professionals, determining the recommended dosage, the manufacturer advising about the possible side effects, and if the subject can use the creatine.

References

American College of Sports Medicene the physiological and health effects of oral creatine supllementation Roundtaple held april 8-10, 2000.

Andrws, R.; Greenhaff, P.; Curtis, S.; Perry, A.; Cowley, A.J. The effect of dietary creatine supplementation on skeletal muscle metabolism in cogestive heart failure. Eur.Heart J. 19:617-622,1998.

Control, C.F.D. Hyperthermia and dehydration-related deathsn associated with intentional rapid weiht loss in three collegiat wrestlers: North Carolina, Wisconsin and Michigan. MMWR 47: 105-108,1998.

Cordon, A.; Hultman, E.; Kaijser, L.; e colaboradores. Creatine supplementation in chronc heart failure increases skeeltal muscle creatine phosphate and muscle performance. Cardiovasc. Res. 30:413-418, 1995.

Grindsta, P.D.; Kreider, R.; Bishop, R.; e colaboradors. Effects of oral creatine supplamentation on repetitive sprint performance and body composition in competitive wimmers. Int. J. Sports Nutr. 7:330-346,1997.

Harris, R.C.; Soderlund, K.; Hultman, E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin. Sci. 83:367-374,1992.

Hespel, P.; Eijnde, B.O.; Derave, W.; e colaboradores. Creatine supplemtation: exploring the role of the creatine kinase / phosfhocreatine system in humam muscle. Com J Appl Physiol 2001; 26 Suppl: 579- S 102.

Hoogwerf, B.J.; Laine, D.C.; Greene, E. Urine C-peptide and creatine (Jaffe Method) excretion in heathy young adults on varied diets: sustained effects of varied carbohydrate, protein, and meat content. Am. J. Clin. Nutr. 43:350-360,1986.

Kreider, R.; Melton, C.; Rasmussen, C.; e colaboradores. Effects of long-term creatine supplementation in renal function end muscle and liver enzyne effux (abstract). Med Sci Sport Exerc. 2001; 33 :S 207.

Kreider, R.B.; Ferreira, M.; Wilson, M.; e colaboradores. Effects of creatine supplementation on body composition, strength and sprint performance. Med. Sci. Sports Exerc.30:73-82,1999.

Jacobsen, F.K.; Christensen, C.K.; Mogensen, C.E.; Andrasen, F. Pronounced increase serum creatinine concentration after eating cooked meat. Br.Med. J. 1 (6170):1049-1050,1979.

Juhn, M.S.; Tarnopolsky, M. Oral creatine supplementation and athletic performance: a critical review. Clin.J. Sport Med. 8:286-297,1998.

Mayersohn, M.; Conrad, K.A.; Acharl, R. The influence of a cooked meat meal on creatinine plasma concentration and creatinine clearance. Br. J. Clin. Pharmacol. 15:227-230,1983.

Messa, J.I.; Ruiz, J.R.; Gonsalez-Gross, M.M.; e colaboradores. Oral creatine supplementation and skeletal muscle metabolism in physical exercise. Sports Med. 2002; 35:95-104.

Michael G. Bemben e Hugh S. Lamont. Creatine supplementation and exercise performance. Sport Med. 35: (2) 107-125, 2006.

Mihic, S.; Macdonald, J.R.; Mckenzie, S.; Tarnopolsky, M.A. Acute creatine loading increase fat-freee mass, butdos not effect blood pressur, plasma creatinine nor CK activity. Med. Sci.Sports. Exerc. ,in press. 17. Oopik, V.; Paasuke, M.; Timpmann, S.; Medijainen, L.; Ereline, J.; Smirnova T. Effect of creatine suplementation during rapid bory mass reducdion on metabolism and esokinetic muscle performance capacity. Eur. J. Appl. Physiol. 78:83-92,1998.

Papado Paulos, C.; Imamura, R.; Brandon, I.J. The effect of creatine supplementation on repeated bauts of high-intesity exercise in the hert (abstract). Med Sci Sports Exerc. 2001;33: S 203.

Pasternack, A.; Juhlback, B. Diurnal variation of serum and urine creatine and creatinine. Scand. J. Clin.Lab. Invest. 27:1-7,1971.

Peeters, B.M.; Lantz, C.D.; Mayhew, J.L. Effect of oral creatine monohydrate and creatine phosphat supplementation on maximal strength indices, bory composition, and blood pressure. J. Strength Condit.Res. 13:3-9,1999.

Poortmans,J.R.; Auguier, H.; Renaut, V.; Durussel, A.; Saugy, M.; Brisson, G.R. Effect of short-term creatine supplementation on renal responses in men. Eur. J. Appl. Physiol. 76:566-567,1997.

Poortmans, J.R.; Francaux, M. Long-term and creatine suplementation does not impair renal function in healthy athets. Med. Sci. Sports Exerc. 31:1108-1110,1999.

Poortman, J.R.; Francaux, M. Adverse effects of creatine supplementation: fact or fiction. Sport Med. 2000; 30 (3)155-70.

Robinson, T.M.; Sewell, D. A.; Casey, A.; e colaboradores. Dietary creatine supplementation does not effect some hemetological, indices, or indices of muscle damage and hepatic anda renal function Br j Sport Med. 2000; 34: 208-08.

Romer, I.M.; Barrinzton, J.P.; Jenkenbrup, A.E. Effects of oral creatine supplementation on high intensity intermittent exercise performance in competitive squash players. Int. J .Sports Med. 2001;22:546-52.

Schilling, B. K.; Stone, M.H.; Vatter, A.; e colaboradores. Creatine supplementation and health variables : a retrospective study. Med Sci Sport Exerc 2001; 33: 103-08.

Schnirring, L. Creatine supplements face scrutiny: will users pay late? Physician Sports Med. 6:1522,1998. 28. Tarnopolsky, M.; Martin, J. Creatine monohydrate increases strength in patients with neuromuscular disease. Neurology. 52:854-857,1999.

Terjung, R.L.; Clarkson, P.; Eichner, E.R. The physilogical and health effect of oral creatine supplementation. Med Sci Sport Exerc. 2000: 32 (3): 706-16.

Vandeberie, F.B.; Vandeneynde, M.; Vandenberghe, K.; Hespel, P. Effect of creatine on endurance capacity and sprint power in cyclists. Ins.J. Sport Med. 8: 2055-2063 ́1998.

Vandenberqueghe, K.; Goris, M.; Van hecke, P.; Van leemputte, M.V.; Van Geruen, L.; Hespel, P. Long-term creatine intake is beneficial to muscle performance during resistance training. J. Appl. Physical. 83: 2055-2063,1997.

Vollek, J.S.; Duncan, M.D.; Mazzetti, S.A.; e colaboradores. Performance and muscle fiber adaptation to creatine suplementation and heavy resistance training. Med. Sci. Sports Exerc. 312:1147-1156,1999.

Published
2012-01-08
How to Cite
Sousa, M. A. de Q., & Azevedo, C. H. G. de. (2012). Creatine supplementation and possible side effects. RBNE - Brazilian Journal of Sports Nutrition, 2(9). Retrieved from https://www.rbne.com.br/index.php/rbne/article/view/58
Section
Scientific Articles - Original