Branched Chain Amino Acids (BCAA) supplementation and its effect on the protein muscle balance and the central fatigue on endurance exercises

  • Camila Luana Wloch Programa de Pós Graduação Lato Senso da Universidade Gama Filho em Bases Nutricionais da Atividade Fí­sica. Nutricionista, graduada pela Universidade do Vale do Itajaí­ (UNIVALI)
  • Gustavo Schneider Programa de Pós Graduação Lato Senso da Universidade Gama Filho em Bases Nutricionais da Atividade Fí­sica. Nutricionista, graduado pela Universidade do Vale do Itajaí­ (UNIVALI)
  • Polyana Carolina de Souza Programa de Pós Graduação Lato Senso da Universidade Gama Filho em Bases Nutricionais da Atividade Fí­sica. Nutricionista, graduada pela Universidade do Vale do Itajaí­ (UNIVALI)
  • Rafaela Liberali Programa de Pós Graduação Lato Senso da Universidade Gama Filho em Bases Nutricionais da Atividade Fí­sica
Keywords: Supplements, BCAA, Endurance

Abstract

The objective of this study was review the effects of BCAA for muscle protein balance and central fatigue in exercise of long duration. It was analyzed 17 international scientific articles and 2 national scientific articles published between 1996 and 2008. In 7 studies were used rats as experimental model and 12 the human model. Among the studies analyzed that used rats, all 7 events had positive effects. Of these, 6 were made with the consumption of leucine alone. Among the studies discussed with people, there were 5 events of positive effects and 7 events with non result. Among the studies with positive effect, most showed improvement related to synthesis protein or proteolysis inhibition on individuals. In most of these studies, the leucine was responsable for these results alone. The theory that BCAA would reduce the central fatigue has much support as rejection in the studies. The vast discrepancy between the experimental protocols used difficulted the analysis of the results. Before this, it was concluded that there is still no sufficient scientific evidence proving categorically the beneficial effect of BCAA intake on the income of physical exercise in endurance.

References

Anthony, J.C.; Anthony, T.G.; Kimball, S.R.; Jefferson, L.S. Signaling Pathways involved in translational control of protein synthesis in skeletal muscle by leucine. J Nutr. v. 131, p. 856S-860S, 2001.

Anthony, J.C.; Anthony, T.G.; Kimball, S.R.; Vary, T.C.; Jefferson, L.S. Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased elF4F formation. J Nutr. v. 130, p. 139-145, 2000b.

Anthony, J.C.; Anthony, T.G.; Layman, D.K. Leucine supplementation enhances skeletal muscle recovery in rats following exercise. J Nutr. v. 129, p. 1102-1106, 1999.

Anthony, J.C.; Reiter, A.K.; Anthony, T.G.; Crozier, S.J.; Lang, C.H.; Maclean, D.A.; Kimball, S.R.; Jefferson, L.S. Orallly administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation. Diabetes. v. 51, p. 928-936, 2002.

Anthony, J.C.; Yoshizawa, F.; Anthony, T.G., Vary, T.C.; Jefferson, L.S.; Kimball, S.R. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr. p. 2413-2419, 2000a.

Araújo, A.C.M. de; Soares, Y. de N.G. Perfil de utilização de repositores protéicos nas academias de Belém, Pará. Rev Nutr. v. 12, n. 1, p. 81-89, 1999.

Bacurau, R.F. Ergogênicos. In: Nutrição e Suplementação Esportiva. 5 ed. São Paulo: Phorte Editora; 2007. p. 257-277.

Bertolucci, P. Nutrição, hidratação e suplementação do atleta: um desafio atual. Nutrição em Pauta. ano 10, n. 54, p. 09-18, 2002.

Blomstrand, E. A role for branched-chain amino acids in reducing central fatigue. J. Nutr. v. 136, p. 544S-547S, 2006.

Blomstrand, E.; Elianon, J.; Karlsoon, H.K. R.; Köhnke, R. Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. J Nutr. v. 136, p. 269S-273S, 2006.

Blomstrand, E.; Saltin, B. BCCA intake affects protein metabolism in muscle after but not during exercise in humans. Am J Physiol Endocrinal Metab. v. 281, p. E365-E374, 2001.

Braggion, G.F. Suplementação alimentar na atividade física e no esporte: aspectos legais na conduta do nutricionista. Nutrição Profissional. v. 4, n. 17, p. 40-50, 2008.

Brosnan, J.T.; Brosnan, M.E. Branched-chain amino acids: enzyme and substrate regulation. J Nutr. v. 136, p. 207S-211S, 2006.

Cheuvront, S.N.; Carter Iii, R.; Kolka, M.A.; Lieberman, H.R.; Kellogg, M.D.; Sawka, M.N. Branched-chain amino acids supplementation and human performance when hypohytdrated in the heat. J Appl Physiol. v. 97, p. 1275-1282, 2004.

Coelho, C. de F.; Camargo, V.R.; Ravagnani, F.C. de P. Consumo de suplementos nutricionais por praticantes de musculação em academias de Campo Grande - MS. Nutrição em Pauta. ano 15, n. 87, p. 41-45, 2007.

Crowe, M.; Weatherson, J.N.; Bowden, B.F. Effects of dietary supplementation on exercise performance. Eur J Appl Physiol. v. 97, p. 664-672, 2006.

Crozier, S.J.; Kimball, S.R.; Emmert, S.W.; Anthony, J.C.; Jefferson, L.S. Oral leucine administration stimulates protein synthesis in rat skeletal muscle. J Nutr. v. 135, p. 376-382, 2005.

Cynober; L.; Harris, R.A. Symposium on branched-chain amino acids: conference summary. J Nutr. v. 136, p. 333S-336S, 2006.

Fernstron, J.D. Branched-chain amino acids and brain function. J Nutr. v. 135, p. 1539S-1546S, 2005.

Gibala, M.J.; Lozej, M.; Tarnopolsky, M.A.; Mclean, C.; Graham, T.E. Low glycogen and branched-chain amino acid ingestion do not impair anlplerosis during exercise in humans. J Appl Physiol. v. 87, p. 1662-1667, 1999.

Gleeson, M. Interrelationship between physical activity and branched-chain amino acids. J Nutr. v. 135, p. 1591S-1595S, 2005.

Hall, G.; Raaymakers, J.S.; Saris, W.H.; Wagenmakers, A.J. Ingestion of branched-chain amino acids and tryptopahn during sustained exercise in man: failure to affect performance. J Physiol. v. 486, p. 789-794, 1995.

Howarth, K.R.; Burgomaster, K.A.; Phillips, S.M.; Gibala, M.J. Exercise training increases branched-chain amino acids oxoacid dehydrogenase kinase content in human skeletal muscle. Am J Physiol Endocrinal Metab. v. 293, p. R1335-R1341, 2007.

Junqueira, J.M.; Maestá, N.; Sakzenian, V.M.; Burini, R.C. Uso de suplementos nutricionais e conhecimentos dietéticos de freqüentadores de academias de Botucatu/SP. Nutrição em Pauta. ano 15, n. 85, p. 57-63, 2007.

Karlsson, H.K.R.; Nilsson, P.A.; Nilsson, J.; Chibalin, A.V.; Zierath, J.R.; Blomstrand, E. Branched-chain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistence exercise. Am J Physiol Endocrinal Metab. v. 287, p. E1-E7, 2004.

Kimball, S.R. Regulation of global and specific mRNA translation by amino acids. J Nutr. v. 132, p. 883-886, 2002.

Kimball, S.R.; Jefferson, L.S. Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J Nutr. v. 136, p. 227S-231S, 2006.

Koopman, R.; Wagenmakers, A.J.M.; Manders, R.J.F.; Zorenc, A.H.G.; Senden, J.M.G.; Gorselink, M.; Keizer, H.A.; Loon, L.J.C. Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo male subjects. Am J Physiol Endocrinal Metab. v. 288, p. E645-E653, 2005.

Layman, D.K. The role of leucine in weight loss diets and glucose homeostasis. J Nutr. v. 133, p. 261S-267S, 2003.

Madsen, K.; Mclean, D.A.; Kiens, B.; Christensen, D. Effects of glucose, glucose plus branched-chain amino acids, or placebo on bike performance over 100 km. J Appl Physiol. v. 81, n.6, p. 2644-2650, 1996.

Marquezi, M.L.; Lancha Junior, A.H. Possível efeito da suplementação de aminoácidos de cadeia ramificada, aspartato e asparagina sobre o limiar anaeróbio. Rev Paul Educ Fís. v. 11, n. 1, p. 90-101, 1997.

Matsumoto, K.; Mizuno, M.; Dilling-Hansen, B.; Lahoz, A.; Bertelsen, V.; Münster, H.; Jordening, H.; Hamada, K.; Doi, T. Brached-chain amino acids and arginine supplementation attenuates skeletal muscle proteolysis induced by moderate exercise in young individuals. Int J Sports Med. v. 28, p. 531-538, 2007.

Mero, A. Leucine supplementation and intensive training. Sports Med. v. 27, n. 6, p. 347-356, 1999.

Norton, L.E.; Layman, D.K. Leucine regulates translations initiation of protein synthesis in skeletal muscle after exercise. J Nutr. v. 136, p. 533S-537S, 2006.

Rieu, I.; Balage, M.; Sornet, C.; Debras, E.; Ripes, S.; Rochon-Bonhomme, C.; Pouyet, C.; Grizard, J.; Dardevet, D. Increased availability of leucine with leucine-rich whey proteins improves postprandial muscle protein synthesis in aging rats. Nutrition. v. 23, p. 323-331, 2007.

Rocha, L.P. da; Pereira, M.V.L. Consumo de suplementos nutricionais por praticantes de exercícios físicos em academias. Rev Nutr. v. 11, n. 1, p. 76-81, 1998.

Rogero, M.M.; Tirapegui, J. Aminoácidos de cadeia ramificada, balanço protéico muscular e exercício físico. Nutrição em Pauta. ano 15, n. 83, p. 28-34. 2007.

Rohlfs, I.C.; Mara, L.S.; Lima, W.S. De; Carvalho, T. de. Relação da síndrome do excesso de treinamento com estresse, fadiga e serotonina. Rev Bras Med Esporte. v. 11, n. 6, p. 367-372, 2005.

Rossi, L.; Castro, I.A.; Tirapegui, J. Suplementação com aminoácidos de cadeia ramificada e alteração na concentração da serotonina cerebral. Nutrire: Rev Soc Bras Alim Nutr. v. 26, p. 01-10, 2003.

Rossi, L.; Tirapegui, J. Serotonina e neuromodulação alimentar. Nutrição em Pauta. ano 13, n. 72, p. 36-40, 2005.

Santos, M.G. Dos; Dezan, V.H.; Sarraf, T.A. Bases metabólicas da fadiga muscular aguda. Rev Bras Ciên e Mov. v. 11, n. 1, p. 07-12, 2003.

Shimomura, Y.; Honda, T.; Shiraki, M.; Murakami, T.; Sato, J.; Kobayashi, H.; Mawatari, K.; Obayashi, M.; Harris, R. Branched-chain amino acid catabolism in exercise and liver disease. J Nutr. v. 136, p. 250S-253S, 2006b.

Shimomura, Y.; Yamamoto, Y.; Bajotto, G.; Sato, J.; Murakami, T.; Shimomura, N.; Kobayashi, H.; Mawatari, K. Nutraceutical effects of branched-chain acids on skeletal muscle. J Nutr. v. 136, p. 529S-532S, 2006a.

Silva, P.A. da; Alves, F. Efeitos da ingestão dos aminoácidos de cadeia ramificada na fadiga central. Revista Portuguesa de Ciências do Desporto v. 5, n. 1, p. 102-113, 2005.

Siminoni, J.; Lopes, M.L.; Rinaldi, M.G.; Simonard-Loureiro, H.M. Perfil da ingestão protéica em praticantes de exercício físico em academias de ginástica de Curitiba - PR. Nutrição Brasil. v. 5, n. 4, p. 205-209, 2006.

Thomas, C.; Perrey, S.; Saad, H.B.; Delage, M.; Dupuy, A.M.; Cristol, J.P. Mercler, J. Int J Sports Med. v. 28, p. 703-712, 2007.

Uchida, M.C.; Bacurau, A.V.N.; Aoki, M.S.; Bacurau, R.F.P. Consumo de aminoácidos de cadeia ramificada não afeta o desempenho de endurance. Rev Bras Med Esporte. v. 14, n. 1, p. 42-45, 2008.

Watson, P.; Shirreffs, S.M.; Maughan, R.J. The effects of acute branched-chain amino acids supplementation on prolonged exercise capacity in a warm environment. Eur J Appl Physiol. v. 93, p. 306-314, 2004.

Williams, M. Suplementos dietéticos e desempenho esportivo. Nutrição em Pauta. ano 12, n. 66, p. 56-60, 2004a.

Williams, M. Suplementos dietéticos e desempenho esportivo: resumo. Nutrição em Pauta. ano 12, n. 69, p. 53-56, 2004b.

Zeiser, C.C.; Silva, R.C.R. da. O uso de suplementos alimentares entre os profissionais de educação física atuantes em academias da cidade de Florianópolis. Nutrição em Pauta. ano 15, n. 86, p. 30-33, 2007.

Published
2012-01-10
How to Cite
Wloch, C. L., Schneider, G., de Souza, P. C., & Liberali, R. (2012). Branched Chain Amino Acids (BCAA) supplementation and its effect on the protein muscle balance and the central fatigue on endurance exercises. RBNE - Brazilian Journal of Sports Nutrition, 2(10). Retrieved from https://www.rbne.com.br/index.php/rbne/article/view/70
Section
Scientific Articles - Original