Efecto del té verde sobre la movilización de lípidos y el estrés oxidativo

  • Érica Blascovi de Carvalho Programa de Pós-Graduação Lato Sensu da Universidade Gama Filho - Bases Nutricionais da Atividade Fí­sica: Nutrição Esportiva
  • Marcella Cesar Victorino Freire Programa de Pós-Graduação Lato Sensu da Universidade Gama Filho - Bases Nutricionais da Atividade Fí­sica: Nutrição Esportiva
  • Isabela Beraldo Neves Programa de Pós-Graduação Lato Sensu da Universidade Gama Filho - Bases Nutricionais da Atividade Fí­sica: Nutrição Esportiva
  • Christiano Bertoldo Urtado Programa de Pós-Graduação Lato Sensu da Universidade Gama Filho - Bases Nutricionais da Atividade Fí­sica: Nutrição Esportiva. Faculdade de Ciências Médicas - UNICAMP
Palabras clave: Té verde, Estrés oxidativo, Lipólisis, Oxidación

Resumen

Introducción: Los efectos benéficos del té verde para la salud, actualmente indicados en estudios, lo convierten en una de las bebidas más consumidas en el mundo. Objetivo: el propósito de este artículo es revisar los principales efectos metabólicos de los constituyentes del té verde y su posible uso para la prevención y/o tratamiento de enfermedades asociadas al estrés oxidativo y la obesidad. Metodología: este estudio es de naturaleza bibliográfica, basado en las bases de datos Scielo, Medline, Biremee Highwire. Revisión de la literatura: las catequinas se han identificado como importantes agentes antioxidantes, mediando la función cardioprotectora del té a través de efectos directos e indirectos sobre el sistema cardiovascular. Sobre el metabolismo de los lípidos, las catequinas actúan estimulando segundos mensajeros capaces de estimular la lipólisis, inhibiendo las enzimas limitantes del proceso, además de aumentar la tasa de oxidación de las grasas. Conclusiones: El consumo de té verde puede tener un potente efecto termogénico y antioxidante. En este sentido, se necesita más evidencia para cuantificar mejor las dosis y el manejo de uso.

Citas

-Ahmadian, M.; Duncan, R.E.; Jaworski,K.; Sarkadi-Nagy, E.; Sul, H.S. Triacylglycerol metabolism in adipose tissue. Future Lipidology. Vol. 2. Núm. 2. 2007. p. 229–237.

-Alexopoulos, N.; Vlachopoulos, C.; Aznaouridis, K.; Baou, K.; Vasiliadou, C.; Pietri, P.; Xaplanteris, P.; Stefanadi, E.; Stefanadis, C. The acute effect of green tea consumption on endothelial function in healthy individuals. European journal of cardiovascular prevention and rehabilitation. Vol. 15. Núm. 3. 2008. p. 300-5.

-Allen, C.L.; Bayraktutan, U. Oxidative stress and its role in the pathogenesis of ischaemic stroke. International Journal of Stroke: Official Journal of the International Stroke Society. Vol. 4. Núm. 6. 2009. p. 461-70.

-Angelo,P.M.; Jorge, N. Compostos fenólicos em alimentos –Uma breve revisão. Revista do Instituto Adolfo Lutz. Vol. 66. Núm. 1. 2006. p. 232-240.

-Bae, J.H.; Bassenge, E.; Kim, K.B.; Kim, Y.N.; Kim, K.S.; Lee, H.J.; Moon, K.C.; Lee, M.S.; Park, K.Y.; Schwemmer, M. Postprandial hypertriglyceridemia impairs endothelial function by enhanced oxidant stress. Atherosclerosis. Vol. 155. 2001. p. 517–23.

-Berube-Parent, S.; Pelletier, C.; Dore, J.; Tremblay, A. Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24h energy expenditure and fat oxidation in men. The British Journal of Nutrition. Vol. 94. 2003. p.432–6.

-Borchardt, R.T.; Huber, J.A. Catechol O-methyltransferase. 5. Structure–activity relationships for inhibition by flavonoids. Journal of Medicinal Chemistry. Vol. 18. 1975. p. 120–2.

-Butt, M.S.; Sultan, M.T. Green tea: nature's defense against malignancies. Critical Reviews in Food Science and Nutrition. Vol. 49. Núm. 5. 2009. p. 463-73.

-Chacko, S.M.; Thambi, P.T.; Kuttan, R.; Nishigaki, I. Beneficial effects of green tea: A literature review. Chinese Medicine. Vol. 5. Núm. 13. 2010. p. 1-9.

-Chan, P.T.; Fong, W.P.; Cheung, Y.L.; Huang, Y.; Ho, W.; Chen, Z.Y. Jasmine green tea epicatechins are hypolipidemic in hamsters (Mesocricetus auratus) feda high fat diet. The Journal of Nutrition. Vol. 129. 1999. p. 1094-1101.

-Chen, D.; Wang, C.Y.; Lambert, J.D.; AI, N.; Welsh, W.J.; Yang, C.S. Inhibition of human liver catechol-O--methyl transferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studies. Biochemical Pharmacology. Vol. 69. Núm. 10. 2005. p. 1523-31.

-Coleman, R.A.; Lee, D.P. Enzymes of triacylglycerol synthesis and their regulation. Progress in Lipid Research. Vol. 43, Núm. 2. 2004. p. 134–176.

-Crespy, V.; Williamson, G. A review of the health effects of green tea catechins in in vivo animal models. The Journal of Nutrition. Vol. 134. Supl. 12. 2004. p. 3431S –3440S.

-Diepvens, K.; Westerterp, K.R.; Westerterp-Plantenga, M.S.Obesity and thermogenesis related to the consumption of caffeíne, ephedrine, capsaicin, and green tea. American Journal of Physiology. Regulatory, integrative and comparative physiology. Vol. 292. Núm. 1. 2007. p. 77-85.

-Dircks, L.; Sul, H.S. Acyltransferases of de novo glycerophospholipid biosynthesis. Progress in Lipid Research. Vol. 38. Núm. 56. 1999. p. 461–479.

-Dulloo, A.G.; Duret, C.; Rohrer, D.; Girardier, L.; Mensi, N.; Fathi, M, Chantre, P.; Vandermander, J. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. The American Journal of Clinical Nutrition. Vol. 70. Núm. 6. 1999. p. 1040-5.

-Dulloo, A.G.; Seydoux, J.; Girardier, L.; Chantre, P.; Vandermander, J. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. International Journal of Obesity and Related Metabolic Disorders. Vol. 24. 2000. p. 252–8.

-Eghwrudjakpor, P.O.; Allison, A.B. Oxidative stress following traumatic brain injury: enhancement of endogenous antioxidant defense systems and the promise of improved outcome. Nigerian Journal of Medicine: Journal of the National Association of Resident Doctors of Nigeria. Vol. 19. Núm. 1. 2010p. 14-21.

-Freitas, H.C.P; Navarro, F. O chá verde induz o emagrecimento e auxilia no tratamento da obesidade e suas comorbidades. Revista Brasileira de Obesidade, Nutrição e Emagrecimento, São Paulo. Vol. 1. Núm. 2. 2007. p. 16-23.

-Gregersen, N.T.; Bitz, C.; Krog-Mikkelsen, I.; Hels, O.; Kovacs, E.M.; Rycroft, J.A.; Frandsen, E.; Mela, D.J.; Astrup, A. Effect of moderate intakes of different tea catechins and caffeine on acute measures of energy metabolism under sedentary conditions. The British Journal of Nutrition. Vol. 102. 2009. p. 1187–94.

-Hampton, M.E. Production of black tea. In: Willson, K.C.; Clifford, M.N. (Eds.). Tea cultivation to consumption. London: Chapman & Hall, 1992. p.459-510.

-Harada, U.; Chikama, A.; Saito, S.; Takase, H.; Nagao, T.; Hase, T.; Tokimitsu, I. Effects of the long-term ingestion of tea catechins on energy expenditure and dietary fat oxidation in healthy subjects. Journal of Health Science. Vol. 51. 2005. p. 248–52.

-Hase, T.; Komine, Y.; Meguro, S.; Takeda, Y.; Takahashi, H.; Matsui, Y.; Inaoka, S.; Katsuragi, Y.; Tokimitsu, I.; Shimasaki, H.; Itakura, H. Anti-obesity effects of tea catechins in humans. Journal of Oleo Science. Vol. 50. 2001. p. 599–605.

-Henning, S.M.; Niu, Y.; Lee, N.H.; Thames, G.D.; Minutti, R.R.; Wang, H.; Go, V.L.W.; Heber, D.Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement. The American Journal of Clinical Nutrition. Vol. 80. 2006. p. 1588-64.

-Higdon, J.V.; Frei, B. Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Critical Reviews in Food Science and Nutrition, Boca Raton. Vol. 43. Núm. 1. 2003. p. 89-143.

-Hung, H.C.; Joshipura, K.J.; Jiang, R.; Hu, F.B.; Hunter, D.; Smith-Warner, S.A.; Colditz, G.A.; Rosner, B.; Spiegelman, D.; Willett, W. C. (2004) Fruit and vegetable intake and risk of major chronic disease. Journal of the National Cancer Institute. Vol. 96. Núm. 21. 2004. p. 1577–84.

-Jaworski, K.; Sarkadi-Nagy, E.; Duncan, R.E.; Ahmadian, M.; Sul, H.S. Regulation of Triglyceride Metabolism. IV. Hormonal regulation of lipolysis in adipose tissue. American Journal of Physiology. Gastrointestinal and Liver Physiology. Vol. 293. Núm. 1. 2007. p. G1–G4.

-Khan, N.; Mukhtar, H. Tea polyphenols for health promotion. Life Sciences, Oxford. Vol. 81. Núm. 7. 2007. p. 519-533.

-Komatsu, T.; Nakamori, M.; Komatsu, K.; Hosoda, K.; Okamura, M.; Toyama, K.; Ishikura, Y.; Sakai, T.; Kunii, D.; Yamamoto, S. Oolong tea increases energy metabolism in Japanese females. The Journal of Medical Investigation.Vol. 50. 2003. p. 170–5.

-Kovacs, E.M.; Lejeune, M.P.; Nijs, I.; Westerterp-Plantenga, M.S. Effects of green tea on weight maintenance after body-weight loss. The British Journal of Nutrition. Vol. 91. 2004. p. 431–7.

-Kozuma, K.; Chikama, A.; Hoshino, E.; Kataoka, K.; Mori, K.; Hase, T.; Katsuragi, Y.; Tokimitsu, I.; Nakamura, H. Effect of intake of a beverage containing 540 mg catechins on the body composition of obese women and men. Progressive Medicine. Vol. 25. 2005. p. 185–97.

-Lamarão, R.C.; Fialho, E. Aspectos funcionais das catequinas do chá verde no metabolismo celular e sua relação com a redução da gordura corporal. Revista de Nutrição, Campinas. Vol. 22. Núm. 2. 2009 p. 257-269.

-Lamprecht, M.; Greilberger, J.; Oettl, K. Analytical Aspects of Oxidatively Modified Substances in Sports and Exercises. Nutrition. Vol. 20. Núm. 7/8. 2004. p. 728-30.

-Langin, D. Adipose tissuelipolysis as a metabolic pathway to definepharmacological strategies against obesity and the metabolic syndrome. Pharmacological Research: the Official Journal of the Italian Pharmacological Society. Vol. 53, Núm. 6. 2006. p. 482–91.

-Leenen, R.; Roodenburg, A.J.; Tijburg, L.B.; Wiseman, S.A. A single dose of tea with or without milk increases plasma antioxidant activity in humans. European Journal of Clinical Nutrition. Vol. 54. Núm. 1. 2000. p. 87-92.

-Lehner, R.; Kuksis, A. Biosynthesis of triacylglycerols. Progress in Lipid Research. Vol. 35. Núm. 2. 1996. p. 169–201.

-Levander, O.A.; Fontela, R.; Morris, V.C.; AgerJr, A.L. Protection against murine cerebral malaria by dietary-induced oxidative stress. The Journal of Parasitology. Vol. 81. Núm. 1. 1995. p. 99–103.

-Liao, S. The medicinal action of androgens and green tea epigallocatechin gallate. Hong Kong Medical Journal. Vol. 7. Núm. 4. 2001. p. 369-74.

-Lima, J.; Mazzafera, P.; Moraes, W.S.; Silva, R.B. Chá: aspectos relacionados à qualidade e perspectivas. Santa Maria. Vol. 39. Núm. 4. 2009. p. 1270-1278.

-Malhotra, J.D.; Miao, H.; Zhang, K.; Wolfson, A.; Pennathur, S.; Pipe, S.W.; Kaufman, R.J. Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proceedings of the National Academy of Sciences of the United States of America. Vol. 105. Núm. 47. 2008. p. 18525-30.

-Matsubara, S.; Rodriguez-Amaya, D. Teores de catequinas e teaflavinas em chás comercializados no brasil. Ciência e Tecnologia de Alimentos, Campinas. Vol. 26. Núm. 2. 2006. p. 401-407.

-Matsuyama, T.; Tanaka, Y.; Kamimaki, I.; Nagao, T.; Tokimitsu, I. Catechin safely improved higher levels of fatness, blood pressure, and cholesterol in children. Obesity.; Vol. 16. Núm. 6. 2008. p. 1338-48.

-Meng, S.J.; YU, L.J. Oxidative stress, molecular inflammation and sarcopenia. International Journal of Molecular Sciences. Vol. 11. Núm. 4. 2010. p. 1509-26.

-Misra, M.K.; Sarwat, M.; Bhakuni, P.; Tuteja, R.; Tuteja, N. Oxidative stress and ischemic myocardial syndromes. Medical Science Monitor: international medical journal of experimental and clinical research. Vol. 15. Núm. 10. 2009. p. 209-219.

-Miyoshi, H.; Perfield2ND, J.W.; Souza, S.C.; Shen, W.J.; Zhang, H.H.; Stancheva, Z.S.; Kraemer, F.B.; Obin, M.S.; Greenberg, A.S. Control of ATGL action by serine 517 of perilipin A globally regulates PKAstimulated lipolysis in adipocytes. The Journal of Biological Chemistry. Vol. 282. 2007. p. 996–1002.

-Miyoshi, H.; Souza, S.C.; Zhang, H.H.; Strissel, K.J.; Christoffolete, M.A.; Kovsan, J.; rudich, A.; Kraemer, F.B.; Bianco, A.C.; Obin, M.S.; Greenberg, A.S. Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. The Journal of Biological Chemistry. Vol. 281. 2006. p. 15837–44.

-Moskaug, J.O.; Carlsen, H.; Myhrstad, M.; Blomhoff, R. Molecular imaging of the biological effects of quercetin and quercetin-rich foods. Mechanisms of Ageing and Development. Vol. 125. Núm. 4. 2004. p. 315–24.

-Nanjo, F.; Hara, Y.; Kikuchi, Y. Effects of tea polyphenols on blood rheology in rats fed a high-fat diet. In: Ho CT, ed. Food phytochemicals for cancer prevention: teas, spices and herbs. Washington, DC: American Chemical Society, 1994. p. 76–82.

-Negishi, H.; Xu, J.W.; Ikeda, K.; Njelekela, M.; Nara, Y.; Yamori, Y. Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats. The Journal of Nutrition. Vol.134. 2004. p. 38-42.

-Osawa, J.L. O chá do município de Registro e seus reflexos na expansão sócio econômica da região. Curitiba: Universidade Federal do Paraná, 1990. 75p.

-Owuor, P.O.; Obanda, M.; Nyirenda, H.E.; Mphangwe, N.I.K.; Wright, L.P.; Apostolides, Z. The relationship between some chemical parameters and sensory evaluations for plain black tea (Camellia sinensis) produced in Kenya and comparison with similar teas from Malawi and South Africa. Food Chemistry, London. Vol. 97. Núm. 4. 2006. p.644-653.

-Papparella, I.; Ceolotto, G.; Montemurro, D.; Antonello, M.; Garbisa, S.; Rossi, G.; Semplicini, A. Green Tea Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Rats by Modulating Reactive Oxygen Species Production and the Src/Epidermal Growth Factor Receptor/Akt Signaling Pathway. The Journal of Nutrition. Vol. 138. Núm. 9. 2008. p. 1596-1601.

-Phung, O.; Baker, W.; Matthews, L.; Lanosa, M.; Thorne, A.; Coleman, C. Effect of green tea catechins with or without caffeine on anthropometric measures: a systematic review and meta-analysis. The American Journal of Clinical Nutrition. Vol. 91. 2010 p. 73–81.

-Rees, J.R.; Burgess, P. Benign mesenteric lipodystrophy presenting as low abdominal pain: a case report. Journal of Medical Case Reports. Vol. 4. 2010. p. 119.

-Ruan, J.; Gerendás, J.; Härdter, R.; Sattelmacher, B. Effect of root zone pH and form and concentration of nitrogen on accumulation of quality-related components in green tea. Journal of the Science of Food and Agriculture, London. Vol. 87, Núm. 8. 2007. p. 1505-1516.

-Rudelle, S.; Ferruzzi, M.G.; Cristiani, I.; Moulin, J.; Mace, K.; Acheson, K.J.; Tappy, L. Effect of a thermogenic beverage on 24-hour energy metabolism in humans. Obesity. Vol. 15. Núm. 2. 2007. p. 349–55.

-Rumpler, W.; Seale, J.; Clevidence, B.; Judd, J.; Wiley, E.; Yamamoto, S.; Komatsu, T.; Sawaki, T.; Ishikura, Y.; Hosoda, K. Oolong tea increases metabolic rate and fat oxidation in men. The Journal of Nutrition. Vol. 131. 2001. p. 2848 –52.

-Schewe, T.; Steffen, Y.; Sies, H. How do dietary flavanols improve vascular function? A position paper. Archives of Biochemistry and Biophysics. Vol. 476. Núm. 2. 2008. p. 102–106.

-Shimizu, M.; Deguchi, A.; Joe, A.K.; Mckoy, J.F.; Moriwaki, H.; Weinstein, I.B. EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon cancer cells. Journal of Experimental Therapeutics & Oncology. Vol. 5. Núm. 1. 2005. p. 69–78.

-Sies, H.; Stahl, W.; Sevanian, A. Nutritional, Dietary andPostprandial Oxidative Stress. The Journal of Nutrition. Vol. 135. Núm. 5. 2005. p. 969–72.

-Soma, M.R. ; Mims, M.P.; Chari, M.V. ; Rees, D.; Morrisett, J.D. Triglyceride metabolism in 3t3-L1 cells. An in vivo 13c Nmr study. The Journal of BiologicalChemistry. Vol. 267. Núm. 16. 1992. p. 11168–11175.

-Tanaka, T.; Kouno, I. Oxidation of tea catechins: chemical structures and reaction mechanism. Food Science and Technology Research. Vol. 9. Núm. 2. 2003. p. 128-133.

-Teresa, S.P.; Moreno, D.A.;Viguera, C.G. Flavanols and Anthocyanins in Cardiovascular Health: A Review of Current Evidence. International Journal of Molecular Science. Vol. 11. 2010. p. 1679-1703.

-Tsai, W.C.; LI, Y.H.; LIN, C.C.; Chao, T.H.; Chen, J.H. Effects of oxidative stress on endothelial function after a high-fat meal. Clinical Science. Vol. 106. Núm. 3. 2004. p. 315–19.

-Victor, V.M.; Apostolova, N.; Herance, R.; Hernandez-Mijares, A.; Rocha, M. Oxidative stress and mitochondrial dysfunction in atherosclerosis: mitochondria-targeted antioxidants as potential therapy. Current Medical Chemistry. Vol. 16. Núm.35. 2009. p. 4654-67.

-Westerterp-Plantenga, M.S. Green tea catechins, caffeine and body-weight regulation. Physiology & Behavior. Vol. 100. Núm. 1. 2010. p.42–46.

-Who. Obesity and overweight, n. 311, 2006. Disponível em: <http://www.who.int/mediacentre/factsheets/fs311/en/index.html> Acesso em 4 de fevereiro de 2010.

-Willcox, J.K.; Ash, S.L.; Catignani, G.L. (2004) Antioxidants and prevention of chronic disease. Critical Reviews in Food Science and Nutrition. Vol. 44. Núm. 4. 2004. p. 275–95.

-Wingler, K.; Müller, C.; Schmehl, K.; Florian, S.; Brigelius-Flohe, R. Gastrointestinal glutathione peroxidase prevents transport of lipid hydroperoxides in CaCo-2 cells. Gastroenterology. Vol. 119. Núm. 2. 2000. p. 420–30.

-Yokozawa, T.; Nakagawa, T.; Kitani, K. Antioxidative activity of green tea polyphenol in cholesterol-fed rats. Journal of Agricultural and Food Chemistry. Vol. 50. Núm. 12. 2002. p. 3549-3552.

-Zhang, H.H.; Souza, S.C.; Muliro, K.V.; Kraemer, F.B.; Obin, M.S.; Greenberg, A.S. Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis. The Journal of Biological Chemistry. Vol. 278. 2003. p. 51535–42.

-Zhang, K. Integration of ER stress, oxidative stress and the inflammatory response in health and disease. International Journal of Clinical and Experimental Medicine. Vol. 3. Núm. 1. 2010. p. 33-40.

-Zhang, K.; Kaufman, R.J. Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo. Methods in Enzymology. Vol. 442. 2008. p. 395-419.

-Zheng, G.; Samaya, K.; Okubo, T.; Juneja, L.R.; Oguni, I. Anti-obesity effectsof three major components of green tea, catechins, caffeine and theanine, in mice. In vivo. Vol. 18. Núm. 1. 2004. p. 55-62.

Publicado
2012-01-13
Cómo citar
Carvalho, Érica B. de, Freire, M. C. V., Neves, I. B., & Urtado, C. B. (2012). Efecto del té verde sobre la movilización de lípidos y el estrés oxidativo. RBNE - Revista Brasileña De Nutrición Deportiva, 4(19). Recuperado a partir de https://www.rbne.com.br/index.php/rbne/article/view/167
Número
Vol. 4 Núm. 19 (2010)
Sección
Artículos Científicos - Original

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