Glutamina y actividad física

  • Mayra de Castro Cardoso Meira Programa de Pós Graduação Lato Sensu em Nutrição Esportiva da Universidade Gama Filho - UGF
  • Rosana Chagas Programa de Pós Graduação Lato Sensu em Nutrição Esportiva da Universidade Gama Filho - UGF
  • Simone Rodrigues Ferreira Programa de Pós Graduação Lato Sensu em Nutrição Esportiva da Universidade Gama Filho – UGF
Palabras clave: Glutamina, Actividad física, Sistema inmunológico, Infección, Músculo

Resumen

La glutamina es el aminoácido más abundante en el cuerpo, es un sustrato importante para algunas células clave del sistema inmunológico. Se ha especulado sobre el uso de la glutamina como una posible ayuda ergogénica, ya que su suplementación ha sido beneficiosa en situaciones clínicas, ya que existe evidencia de que este aminoácido es importante para la funcionalidad de los leucocitos. Sin embargo, aún no se ha determinado el efecto preciso de la glutamina sobre la actividad física. Se observa que la actividad de la glutamina está relacionada con el tipo e intensidad del ejercicio a practicar. Después de una actividad intensa, la concentración plasmática de este aminoácido disminuye, suprimiendo la función inmunológica y haciendo al deportista más susceptible a infecciones de las vías respiratorias superiores. Sobre la base de los datos disponibles, se observa que la actividad física intensa y la nutrición tienen diferentes influencias sobre el sistema inmunitario. Los estudios también relacionan la ingestión de glutamina oral sola después del ejercicio y la ingestión de carbohidratos y glutamina juntas sobre el efecto del almacenamiento de glucógeno en el músculo. Este artículo, sin embargo, revisa algunos análisis sobre el efecto de la suplementación con glutamina sobre los músculos y sobre el sistema inmunológico en practicantes de actividad física.

Citas

Abbas, K.; Lichtman, A.H.; Pober, J.S. Cellular and molecular immunology. Philadelphia: W.B. Saunders Company, 1997. p.4 –14.

Alan, L. Buchman. Glutamine: Is It A Conditionally Required Nutrient For The Human Gastrointestinal System.Jornal of the American College of Nutrition , vol.15, n.3, 199-205- 1996.

Blanchard, M.A.; Jordan, G.; Desbrow, B.; Mackinnon, L. T.; Jenkins, D.G. The influence of diet and exercise on muscle and plasma glutamine concentrations. Med. Sci. Sports Exerc., Vol. 33, No. 1, 2001, pp. 69-74.

Bowtell, J.L.; Gelly, K.; Jackman, M.L.; Patel, A.; Simeoni, M.; Rennie, M.J. Effect of oral glutamine on whole body carbohydrate storage during recovery from exhaustive exercise.J.Appl.Physiol.,v. 86, p. 1770-1777, 1999.

Calich, V.L.G.; Vaz, C.A.C. Imunologia básica. São Paulo: Artes Médicas,1988. p.11-38.

Castell, L.M.; Newsholme, E. A. The effect of oral glutamine supplementation on athletes after prolonged, exhaustive exercise. Nutrition, v. 13, p. 738-742, 1997.

Castell, L. M.; Poortmans, J.R.; Newsholme, E.A. Does glutamine have a role in reducing infections in athletes. Eur. J. Appl. Physiol., v. 73, p. 488-490, 1996.

Curi, R. Glutamina: metabolismo e aplicações clínicas e no esporte. Rio de Janeiro: Sprint: 2000. p. 243-255.

Curi, R. Metabolismo do linfócito e sua regulação. São Paulo, 1993.36p [ Tese de Livre-docência- Instituto de Ciências Biomédicas da Universidade de São Paulo].

Frisina, J.P.; Gaudieri, S.; Cable, T.; Keast, D.; Palmer, T.N. Effects of acute exercise on lymphocyte subsets and metabolic activity. Ind. J. Sports Med., v. 15, p. 36-41, 1994.

Fürst, P.; Stehle, P. Glutamine and glutamine-containing dipeptides. Amino acid metabolism and therapy in health and nutrition disease. New York: CRC Press, 1995. p. 373-383.

Goldberg, A.L.; Chang, T.W. Regulation and significance of amino acid metabolism in skeletal muscle. Fed. Proc., v. 37. 2301-2307, 1978.

Hall, G.; Saris, W.H.M.; Van De Schoor, P.A.I.; Wagenmakers, A.J.M. The Effect of free Glutamine and Peptide Ingestion on The Rate of Muscle Glycogen Resynthesis in Man. Int J Sports Med 1999; 20: 25-30

Hall, G.V.; Wagenmakers, A.J.M. Effect of carbohydrate supplementation on plasma glutamine during prolonged exercise and recovery. Ind. J. Sports Med., v. 19, p. 82-86, 1998.

Hood, D.A.; Terjung, R.L. Amino acid metabolism during exercise and following endurance training. Spors Med., v. 9, p. 23-35, 1990.

Hood, D.A.; Terjung, R.L. Endurance training alters alanine and glutamine release from muscle during contractions. FEBS Lett., v. 340, p. 287-290, 1994.

Hopper, S.L.; Mackinnon, L.T. Plasma glutamine and upper respiratory tract infection during intensified training in swimmers. Med Sci Sports Exerc 1996 Mar: 28(3):285-90.

Janet M. Lacey; Douglas W. Wilmore. Is Glutamine A Conditionally Essential Aminoacid? Nutrition Review/ Vol. 48, n. 8, August 1990.

Katharina S. Kuhn; P. Stehle Furst. Glutamine Content Of Protein And Peptide- Based Enteral Products.Journal of Parenteral and Enteral Nutrition, vol. 2, 1996

Mackinnon, L.T. Immumty in athletes. Int J Sports Med. 1997:18(Suppl 1): S62-S68.

Mackinnon, L.T.; Hooper, S.L. Plasma glutamine and upper respiratory tract during intensified training in swimmers. Med. Sci. Sport. Exerc., v. 28, p. 285-290, 1996.

Newsholme, P. ; Curi, R.; Pithon-Curi, T.C.; e colaboradores. Glutamine matabolism by lymphocytes, macrophages, and neurophils: it importance in health and discease. J Nurt Biochem 1999:10:316-24.

Newsholme, E. A.; Newsholme, P.; Curi, R.; Crabtree, B.; Ardawi, M.S.M. Glutamine metabolism in different tissues. Its physiological and pathological importance. In: KINNEY, J. M., BORUM, P. R., Eds. Perspectives in Clinical Nutrition. Munich: Urban & Scwarzenberg, 1989. p. 71-98.

Nieman, D.C. Imune response to heavy exertion. J Appl Physiol 1997:82: 1385-94.

Nieman, D.C.; Pedersen, B.K. Exercise and immune function. Sports Medicine, v. 27, p. 73-80, 1999.

Parry-Billings, M.; Budgett, R.; Koutedakis, Y.; Blmstrand, E.; Brooks, S.; Baigrie, R.; Newsholme, E.A. Plasma amino acid concentration in the overtraining syndrome: possible effects on the immune system. Med. Sci. Sport. Exerc., v. 24, p. 1353-13558, 1992.

Pedersen, B.K.; Bruunsgaard, H.; Klokker, M.; Kappel, M.; Maclean, D.A.; Nielsen, H.B.; e colaboradores. Exercise-induesd immunomodulation –Possible roles of neuroendocrine and metabolic factors. Ind J Sports Med 1997:18(Suppl 1):S2-S7.

Peters, E.M.; Goetzsche, J.M.; Grobbelaar, B.; Noakes, T.D. Vitamin C supplementation reduces the incidence of post-race symptoms of upper respiratory tract infection in ultramarathon runners. Am. J. clin. Nutr. 1993:57:170-4.

René R. W. J. Der Hulst; Maarten F. Von Meyenfeldt; Niocolaas E. P. Deutz; Reinhold W. Stock Brugger; Peter B. Soeters. Journal Of Surgical Research 61, 30 – 31 (1996). The Effect of Glutamine Administration on Intestinal Glutamine Content.

Rowbottom, D.G.; Keast, D.; Goodman, C.; Morton, A.R. The haematological, biochemical profile of athletes suffering from the overtraining syndrome. Eur.J.Appl. Physiol., v. 70, p. 502-509, 1995.

Rowbottom, D.G.; Keast, D.; Morton, A.R. The emerging role of glutamine as an indicatorof exercise stress and overtraining. Sprots Med., v. 21, p.80-97, 1996.

Thomas R. Ziegler,; Kathleen Benfell, R.PH.; Robert Smith, M.D.; Loraine S. Toung, R.D.; Elaine Brown, M.S.; Elisabeth Ferrari Baliviera; Daniel K. Lowe; Douglas W. Wilmore. Journal of Parenteral and Enteral Nutrition, vol.14,n.4,1999. Safety And Metabolic Effects of L-Glutamine Administration In Humans,1990.

Wagenmakers, A.J. Muscle amino acid metabolism at rest and during exercise: role in human physiology and metabolism. Exerc. Sport. Sci. Rev., v. 26, p. 287-314,1998.

Walsh, N.P.; Blannin, A.K.; Robson, P.J.; Gleeson, M. Glutamine, exercise and immune function: links and possible mechanisms. Sports Med., v. 26, p. 177-191, 1998.

Wiley, W.; Souba, M.D.; Robert, J.; Smith, M.D.; Douglas Wilmore. Glutamine Metabolism By The Intestinal Tract. By The American Society For Parenteral And Enteral Nutrition vol. 9, n. 6.,1985

Williams, B.D.; Chinkes, D.L.; Wolfe, R.R. Alanine and glutamine kinetics at rest and during exercise in humans. Med. Sci. Sport. Exerc., v. 30, p. 1053-1058, 1998.

Windmueller, H.G. Glutamine utilization by the small intestine. In: Meister, A., ed. Advances in enzymology and related areas of molecular biology. New York: John Wiley & Sons, v. 53, p. 201-237, 1982.

Zanker, C.L.; Swaine, I.L.; Castell, L.M.; Newsholme, E.A. Responses of plasma glutamine, free tryptophan and branched-chain amino acids to prolonged axercise after a regime designed to reduce muscle glycogen. Eur. J. Appl. Physiol., v. 75, p. 543-548, 1997.

Zhang, W.; Frankel, M.D.; Bain, B.A.; Chor, B.A.; Klurfeld, J.L.; Rombeau, M.D. Glutamine Reduces Bacterial Translocation After Small Bowel Transplantion In Cyclosporine – Treated Rats.- Journal of Surgical Research 58, 159-164, 1999.

Publicado
2012-01-06
Cómo citar
Meira, M. de C. C., Chagas, R., & Ferreira, S. R. (2012). Glutamina y actividad física. RBNE - Revista Brasileña De Nutrición Deportiva, 1(5). Recuperado a partir de https://www.rbne.com.br/index.php/rbne/article/view/41
Sección
Artículos Científicos - Original