Applicabilità di zingiber officinale roscoe nella riduzione del dolore muscolare a insorgenza ritardata (DMIR) in individui sani che praticano attività fisica: una revisione sistematica

  • Henrique Sasse Avena Núcleo de Nutrição Esportiva da UNIFACS (NEU), Universidade Salvador (UNIFACS), Escola de Ciências da Saúde, Salvador, Bahia, Brasil.
  • Leila Magda Rodrigues Almeida Universidade Salvador (UNIFACS), Escola de Ciências da Saúde, Salvador, Bahia, Brasil
Parole chiave: Dolore musculare, Zingiber officinale, Zenzero, Esercizio fisíco, Antidolorífico

Abstract

Indipendentemente dal fatto che l'individuo sia un atleta ad alte prestazioni, un atleta dilettante o un praticante di esercizio fisico, il desiderio di prestazione e di partecipare alle competizioni ha diffuso allenamenti ad alta intensità. Il dolore muscolare a insorgenza ritardata (DOMS), che inizia circa 24 ore dopo lo stress e può durare fino a 7 giorni, è una conseguenza di un allenamento intenso o di una competizione. Pertanto, l'automedicazione dei farmaci antinfiammatori non steroidei (FANS) è diventata un luogo comune per le persone affette da DOMS. Tuttavia, a causa degli effetti collaterali dell'uso cronico dei FANS, i professionisti dello sport cercano soluzioni sostenibili per i DOMS, in questo contesto Zingiber officinale emerge come una possibile alternativa all'uso dei FANS. Pertanto, l'obiettivo di questa revisione sistematica è valutare l'efficacia della supplementazione di Zingiber officinale nell'alleviare il dolore muscolare a insorgenza ritardata. A tal fine è stata effettuata una ricerca elettronica su articoli scientifici, pubblicati tra il 2000 e il 2019, indicizzati nelle banche dati PubMed, Scientific Electronic Library Online (SciELO) e Virtual Health Library (BVS). Nonostante la diversità dei protocolli di danno muscolare (esercizio di resistenza o resistenza) e l'integrazione (standardizzazione, dose e durata), l'integrazione con Zingiber officinale è stata in grado di ridurre i DOMS nel 77,8% degli studi. Inoltre, sono ancora necessari studi per migliorare la comprensione del DMIT e definire il meccanismo d'azione dello Zingiber officinale, al fine di evitare adattamenti indesiderati.

Biografie autore

Henrique Sasse Avena, Núcleo de Nutrição Esportiva da UNIFACS (NEU), Universidade Salvador (UNIFACS), Escola de Ciências da Saúde, Salvador, Bahia, Brasil.

Nutricionista membro do Núcleo de Nutrição Esportiva da UNIFACS (NEU).

Leila Magda Rodrigues Almeida, Universidade Salvador (UNIFACS), Escola de Ciências da Saúde, Salvador, Bahia, Brasil

Nutricionista. Mestre em Ciências de Alimentos. Especialista em Nutrição Clí­nica.

Riferimenti bibliografici

Barnett, A. Using recovery modalities between training sessions in elite athletes. Sports medicine. Vol. 36. Num. 9. 2006. p. 781-796.

Black, C.D.; O’Connor, P.J. Acute effects of dietary ginger on quadriceps muscle pain during moderate-intensity cycling exercise. International journal of sport nutrition and exercise metabolism. Vol. 18. Num. 6. 2008. p. 653-664.

Black, C.D.; O'Connor, P.J. Acute effects of dietary ginger on muscle pain induced by eccentric exercise. Phytotherapy Research. Vol. 24. Num. 11. 2010. p. 1620-1626.

Black, C.D.; Herring, M.P.; Hurley, D.J.; O’Connor, P.J. Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise. The Journal of Pain. Vol. 11. Num. 9. 2010. p. 894-903.

Buford, T.W.; Cooke, M.B.; Shelmadine, B.D.; Hudson, G.M.; Redd, L.; Willoughby, D.S. Effects of eccentric treadmill exercise on inflammatory gene expression in human skeletal muscle. Applied Physiology, Nutrition, and Metabolism. Vol. 34. Num. 4. 2009. p. 745-53.

Nagendra chari, K.L.; Manasa, D.; Srinivas, P.; Sowbhagya, H.B. Enzyme-assisted extraction of bioactive compounds from ginger (Zingiber officinale Roscoe). Food Chemistry. Vol. 139. Num. 1-4. 2013 p. 509-514.

Charlier, C.; Michaux, C. Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs. European Journal of Medicinal Chemistry. Vol. 38. Num. 7-8. 2003. p. 645-659.

Cheung, K.; Hume, P.A.; Maxwell, L. Delayed onset muscle soreness. Sports Medicine. Vol. 33. Num. 2. 2003. p. 145-164.

Dabague, I.C.M.; Deschamps, C.; Mógor, A.F.; Scheer, A.P.; Côcco, L. Essential oil yield and composition of ginger (Zingiberofficinale Roscoe) rhizomes after different drying periods. Revista Brasileira de Plantas Medicinais. Vol. 13. Num. 1. 2011. p. 79-84.

Dugasani, S.; Pichika, M.R.; Nadarajah, V.D.; Balijepalli, M.K.; Tandra, S.; Korlakunta, J.N. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. Journal of Ethnopharmacology journal. Vol. 127. Num. 2. 2010. p. 515-520.

Fernandes, T.L.; Pedrinelli, A.H.; Arnaldo, J. Lesão muscular -fisiopatologia, diagnóstico, tratamento e apresentação clínica. Revista Brasileira de Ortopedia. Vol. 46. Num. 3. 2011. p. 247-255.

Ghasemzadeh, A.; Jaafar, H.Z.E.; Baghdadi, A.; Tayebi-Meigooni, A. Formation of 6-, 8-and 10-Shogaol in Gingerthrough Application of Different Drying Methods: Altered Antioxidant and Antimicrobial Activity. Molecules. Vol. 23. Num. 7. 2018. p. 1646-1657.

Harirforoosh, S.; Asghar, W.; Jamali, F. Adverse Effects of Nonsteroidal Antiinflammatory Drugs: An Updateof Gastrointestinal, Cardiovascular and Renal Complications. Journal of Pharmacy & Pharmaceutical Sciences. Vol. 16. Num. 5. 2013. p. 821-847.

Hoseinzadeh, K.; Daryanoosh, F.; Baghdasar, P.J.; Alizadeh, H. Acute effects of ginger extract on biochemical and functional symptoms of delayed onset muscle soreness. Medical Journal of the Islamic Republic of Iran. Vol. 29. Num. 1. 2015. p. 261-270.

Hyldahl, R.D.; Hubal, M.J. Lengthening our perspective: morphological, cellular, and molecular responses to eccentric exercise. Muscle & Nerve. Vol. 49. Num. 2. 2014. p. 155-70.

Ko, M.J.; Nam, H.H.; Chung, M.S. Conversion of 6-gingerol to 6-shogaol in ginger (Zingiber officinale) pulp and peel during subcritical water extraction. Food Chemistry. Vol. 270. 2019. p. 149-155.

Kou, X.; Ke, Y.; Wang, X; Rahman, M.R.T.; Xie, Y.; Chen, S.; Wang, H. Simultaneous extraction of hydrophobic and hydrophilic bioactive compounds from ginger (Zingiber officinale Roscoe). Food Chemistry. Vol. 257. 2018. p. 223-229.

Lee, S.; Khoo, C.; Halstead, C.W.; Huynh, T.; Bensoussan, A. Liquid Chromatographic Determination of 6-, 8-, 10-Gingerol, and 6-Shogaol in Ginger (Zingiber officinale) as the Raw Herb and Dried Aqueous Extract. Journal of AOAC International. Vol. 90. Num. 5. 2007. p. 1219-1226.

Lewis, P.B.; Ruby, D.; Bush-Joseph, C.A. Muscle Soreness and Delayed-Onset Muscle Soreness. Clinics in Sports Medicine. Vol. 31. Num. 2. 2012. p. 255-262.

Mao, Q.Q.; Xu, X.Y.; Cao, S.Y.; Gan, R.Y.; Corke, H.; Beta, T.; Li, H.B. Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe). Foods. Vol. 8. Num. 6. 2019. p. 185.

Mashhadi, N.S.; Ghiasvand, R.; Askari, G.; Feizi, A.; Hariri, M.; Darvishi, L.; Barani, A.; Taghiyar, M.; Shiranian, A.; Hajishafiee, M. Influence of Ginger and Cinnamon Intake on Inflammation and Muscle Soreness Endued by Exercise in Iranian Female Athletes. International Journal of Preventive Medicine. Vol. 4. Num. 1. 2013. p. 18-22.

Matsumura, M.D.; Zavorsky, G.S.; Smoliga, J.M. The Effects of Pre-Exercise Ginger Supplementation on Muscle Damage and Delayed Onset Muscle Soreness. Phytotherapy Research. Vol. 29. Num. 6. 2015. p. 887-893.

Miller, S. B. Prostaglandins in Health and Disease: An Overview. Seminars in Arthritis and Rheumatism. Vol. 36. Num. 1. 2006. p. 37-49.

Mizumura, K.; Taguchi, T. Delayed onset muscle soreness: Involvement of neurotrophic factors. The Journal of Physiological Sciences. Vol. 66. Num. 1. 2015. p. 43-52.

Monteiro, E.C.A.; Trindade, J.M.F.; Duarte, A.L.B.P.; Chahade, W.H. Os antiinflamatórios não esteroidais (AINEs). Temas de Reumatologia Clínica. Vol. 9. Num. 2. 2008. p. 53-63.

Murase, S.; Terazawa, E.; Hirate, K.; Yamanaka, H.; Kanda, H.; Noguchi, K.; Ota, H.; Queme, F.; Taguchi, T.; Mizumura, K. Upregulated glial cell line‐derived neurotrophic factor through cyclooxygenase‐2 activation in the muscle is required for mechanical hyperalgesia after exercise in rats. The Journal of Physiology. Vol. 591. Num. 12. 2013. p. 3035-3048.

Ok, S.; Jeong, W.S. Optimization of Extraction Conditions for the 6-Shogaol-rich Extract from Ginger (Zingiber officinale Roscoe). Preventive Nutrition and Food Science. Vol. 17. Num. 2. 2012. p. 166-171.

Ota, H.; Katanosaka, K.; Murase, S.; Furuyashiki, T.; Narumiya, S.; Mizumura, K. EP2 receptor plays pivotal roles in generating mechanical hyperalgesia after lengthening contractions. Scandinavian Journal of Medicine & Science in Sports. Vol. 28. Num. 3. 2017. p. 826-833.

Ota, H.; Katanosaka, K.; Murase, S.; Kashio, M.; Tominaga, M.; Mizumura, K. TRPV1 and TRPV4 play pivotal roles in delayed onset muscle soreness. PLoS One. Vol. 8. Num. 6. 2013. p. 65751.

Owens, D.J.; Twist, C.; Cobley, J.N.; Howatson, G.; Close, G.L. Exercise-induced muscle damage: What is it, what causes it and what are the nutritional solutions? European Journal of Sport Science. Vol. 19. Num. 1. 2019. p. 71-85.

Patapoutian, A.; Tate, S.; Woolf, C.J. Transient receptor potential channels: targeting pain at the source. Nature Reviews Drug Discovery. Vol. 8. 2009. p. 55-68.

Peake, J.M.; Neubauer, O.; Della Gatta, P.A.; Nosaka, K. Muscle damage and inflammation during recovery from exercise. Journal of Applied Physiology. Vol. 122. Num. 3. 2017. p. 559-570.

Peng, S.; Yao, J.; Liu, Y.; Duan, D.; Zhang, X.; Fang, J. Activation of Nrf2 target enzymes conferring protection against oxidative stress in PC12 cells byginger principal constituent 6-shogaol. Food & Function. Vol. 6. Num. 8. 2015. p. 2813-2823.

Rose, E.H.; Feder, M.G.; Pedroso, P.R.; Guimarães, A.Z. Uso referido de medicamentos e suplementos alimentares nos atletas selecionados para controle de doping nos Jogos Sul-Americanos. Revista Brasileira de Medicina do Esporte. Vol. 12. Num. 5. 2006. p. 239-242.

Sarip, M.S.M.; Morad, N. A.; Ali, N.A.M.; Yusof, Y.A.M.; Yunus, M.A.C. The kinetics of extraction of the medicinal ginger bioactive compounds using hot compressed water. Separation and Purification Technology. Vol. 124. 2014. p. 141-147.

Schwertner, H.A.; Rios, D.C. High-performance liquid chromatographic analysis of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol in ginger-containing dietary supplements, spices, teas, and beverages. Journal of Chromatography B. Vol. 856. Num. 1-2. 2007. p. 41-47.

Shen, W.; Li, Y.; Zhu, J.; Schwendener, R.; Huard, J. Interaction between macrophages, TGF-beta1, and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injury. Journal of Cellular Physiology. Vol. 214. Num. 2. 2008. p. 405-412.

Tjendraputra, E.; Tran, V.H.; Liu-Brennan, D.; Roufogalis, B.D.; Duke, C.C. Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells. Bioorganic Chemistry. Vol. 29. Num. 3. 2001. p. 156-163.

Trappe, T.A.; Carroll, C.C.; Jemiolo, B.; Trappe, S.W.; Døssing, S.; Kjaer, M.; Magnusson, S.P. Cyclooxygenase mRNA expression in human patellar tendon at rest and after exercise. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. Vol. 294. No. 1. 2008. p. R192-R199.

Trappe, T.A.; Liu, S.Z. Effects of prostaglandins and COX-inhibiting drugs on skeletal muscle adaptations to exercise. Journal of Applied Physiology. Vol. 115. Num. 6. 2013. p. 909-919.

Tscholl, P.; Junge, A.; Dvorak, J. The use of medication and nutritional supplements during FIFA WorldCups 2002 and 2006. British Journal of Sports Medicine. Vol. 42. Nun. 9. 2008. p. 725-730.

Van Breemen, R.B.; Tao, Y.; Li, W. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia. Vol. 82. Num. 1. 2011. p. 38-43.

Warner, D.C.; Schnepf, G.; Barrett, M.S.; Dian, D.; Swigonski, N.L. Prevalence, attitudes, and behaviors related to the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in student athletes. Journal of Adolescent Health. Vol. 30. Num. 3. 2002. p.150-153. 2002.

Weinheimer, E.M.; Jemiolo, B.; Carroll, C.C.; Harber, M.P.; Haus, J.M.; Burd, N.A.; LeMoine, J.K.; Trappe, S.W.; Trappe, T.A. Resistance exercise and cyclooxygenase (COX) expression in human skeletal muscle: implications for COX-inhibiting drugs and protein synthesis. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. Vol. 292. No. 6. 2007. p. R2241-R2248.

Wilson, P.B. A Randomized Double-Blind Trial of Ginger Root for Reducing Muscle Soreness and Improving Physical Performance Recovery Among Experienced Recreational Distance Runners. Journal of Dietary Supplements. 2018. p. 1-12.

Yu, Y.; Zick, S.; Li, X.; Zou, P.; Wright, B.; Sun, D. Examination of the Pharmacokinetics of Active Ingredients of Ginger in Humans. The AAPS Journal. Vol. 13. Num. 3. 2011. p.1-2.

Zick, S.M.; Djuric, Z.; Ruffin, M.T.; Litzinger, A.J.; Normolle, D.P.; Alrawi, S.;Feng, M.R.; Brenner, D.E. Pharmacokinetics of 6-Gingerol, 8-Gingerol, 10-Gingerol, and 6-Shogaol and Conjugate Metabolites in Healthy Human Subjects. Cancer Epidemiology Biomarkers & Prevention. Vol. 17. Num. 8. 2008. p. 1930-1936.

Pubblicato
2021-05-20
Come citare
Sasse Avena, H., & Almeida, L. M. R. (2021). Applicabilità di zingiber officinale roscoe nella riduzione del dolore muscolare a insorgenza ritardata (DMIR) in individui sani che praticano attività fisica: una revisione sistematica. RBNE - Giornale Brasiliano Di Nutrizione Sportiva, 14(85), 136-151. Recuperato da https://www.rbne.com.br/index.php/rbne/article/view/1616
Sezione
Articoli Scientifici - Original